Dollinger index

526 ENTREPRENEURSHIP CASE

SOURCE: Joel Ruet et al., Biotechnology in India, Les biotechnologies en Inde, 2001, http://www.cerna.ensmp.fr/Documents/
AM-JR-MHZ-BiotechReport.pdf.

Step 1

Identifying and

cloning the gene

of interest

Step 2

Creating the

hybrid cell

Step 3

Producing recombinant

protein through expression of

the inserted gene on an

industrial scale involving

fermentation and purification

Step 4

Getting regulatory

approvals for the

product

Step 5

Marketing the

final product

EXHIBIT 7 Lab-to-Market Value Chain (for a Bio-pharmaceutical Product)

Lab Scale Factory Scale

Field Scale Legal & Clinical Scale

½

¾ ¾

½

Year

2003

2004

2005

Partner

CIMAB

Cuba

Vaccinex

USA

Nobex Corp

USA

Objectives

Develop monoclonal antibodies and cancer vaccines

Focus on antibody products directed at cancer, inflammation

and auto-immune diseases

Identify promising antibody candidates and move them

rapidly into clinical development

Discover and co-develop at least four therapeutic anti-body

products

Develop an oral peptide product for the treatment of

cardiovascular diseases

Jointly develop an oral insulin for treating diabetes on a

global scale

EXHIBIT 9 Biocon’s Partnerships: Feeding the Discovery Pipeline

SOURCE: Biocon files.