aminophylline 238
plasma concentration monitoring 43
4-aminoquinolines 362–3
8-aminoquinolines 364
aminosalicylates 255
amiodarone 221, 224–5
interaction with warfarin 208
monitoring 42–3
amitriptyline, migraine prophylaxis 144
amlodipine 191
ammonia 260
ammonium chloride 279
amoxicillin 326
amphetamines 438–9
on appetite 263
urinary pH and 32
amphotericin 341
ciclosporin and 402
flucytosine with 344
ganciclovir and 347
platinum compounds and 374
ampicillin 326
rash 55, 65
amprenavir 356
amyl nitrate 442
amyotrophic lateral sclerosis 129
anabolic steroids 314
abuse 442
for aplastic anaemia 395
ciclosporin and 402
anaemiaseeaplastic anaemia; folate; haemolytic
anaemia; iron; vitamin B 12
anaesthesia 145–54
2 -adrenoceptor agonists 150
benzodiazepines 149
on fetus 46
H 2 -receptor antagonists 250
inhalational 145–8
intravenous 148–9
malignant hyperthermia 80 , 83–4, 152
muscle relaxants 150–2
opioids 149–50
pregnancy 48–9
premedication 150
see alsolocal anaesthesia
analgesics 156–64
migraine 142
myocardial infarction 198
nitrous oxide as 147
postoperative 163–4
pregnancy 48
terminal care 162–3
anandamide 7
anaphylaxis 404, 405, 406
anastrazole 384
Ancylostoma duodenale, drugs for 365
androgens 313–14
baldness 412
angina 196–8
unstable 196, 198–200
angioplasty, coronary 197–8, 199, 200
angiotensin-converting enzyme inhibitors
187–8
ciclosporin and 402
elderly patients 59
heart failure 213
ischaemic heart disease 199, 200, 201
renal failure 37
angiotensin receptor blockers 188–9
elderly patients 59
heart failure 213–14
ischaemic heart disease 199–200, 201
anidulafungin 343
animal studies 4, 87
anion-exchange resins 181 , 182
anorectic drugs 262–4
antacids 249, 250
mycophenolate mofetil and 403
reflux oesophagitis 252
tetracyclines and 329
antagonists 6, 8–9
competitive 8, 9 , 10
on effect of partial agonists 9
dose–response curves 6
anterior pituitary hormones 316–18
anthracyclines 377–8
anti-androgens 314, 318
anti-Bcl-2 oligonucleotide 382
anti-CD3 antibody 403
anti-D immunoglobulin 408
anti-dysrhythmic drugs
classification 218, 219
plasma concentration monitoring 42–3
anti-emetics 253–5
with cytotoxic drugs 370
migraine 142
with opioids 163
pregnancy 48–9
anti-epileptic drugs seeanticonvulsants
anti-HIV drugs 353–7
interaction with garlic 98
anti-oestrogens, for malignant disease 384
anti-parkinsonian drugs, elderly patients 58
anti-progestogens 311
anti-proliferative immunosuppressants 402–3
anti-sense oligonucleotides 95
antibiotics 323–33
acne 411
antacids and 249
chronic obstructive pulmonary disease 236
combinations 72
cytotoxic 377–8
in cytotoxic chemotherapy 371
elderly patients 59
eye infections 427
pregnancy 48
warfarin and 208
see alsoaminoglycosides
anticholinergic drugs 114, 128
chronic obstructive pulmonary disease 236
mydriatics 425
see alsomuscarinic receptors, antagonists
anticholinesterases 130, 131–2
reversal of muscle relaxants 151
anticoagulants 204, 205–8
combined oral contraceptives and 310
DC cardioversion 221
pregnancy 50, 209
sulphonamides and 330
thyroid disease 39
anticonvulsants 133–41
interaction with corticosteroids 74
plasma concentration monitoring 42
pregnancy 49
antidepressants 116–23
drug interactions 118
elderly patients 58
see alsotricyclic antidepressants
antidiuretic hormone 276–7
antagonists 318
antidotes 72, 446, 447
antifolate analogues 374–5
antihistamines 241, 405–6
eye 427
for vomiting 253–4
antihypertensive drugs 186–95
elderly patients 58
non-steroidal anti-inflammatory drugs and
168
antilymphocyte globulin 403
antiplatelet drugs 208–9
antipseudomonal penicillins 326antipsychotic drugs 111–15
antiretroviral agents seeanti-HIV drugs
antithrombin III 206
antithyroid drugs 39, 293–5
1 -antitrypsin deficiency 242–3
antitussives 242
antiviral agents 344–9
eye 427
influenza 348
nucleoside analogues 345–7
pregnancy 48
see alsoanti-HIV drugs
anxiety 107–9
anxiolytics 105, 106 , 107–9
aorta, dissecting aneurysms, -adrenoceptor
antagonists 189–90
aplastic anaemia 69, 395
chloramphenicol 328, 395
apnoea, suxamethonium sensitivity 80 , 81–2,
152
apolipoprotein A 179
apparent volume of distribution 12
pregnancy 47
appetite stimulation 264
appetite-suppressing drugs 262–4
apraclonidine 426
aqueous humour circulation 425
arachidonic acid 268
cytochrome P450 enzymes on 24–5
metabolism 168
arachis oil 257
aripiprazole 114
aromatase inhibitors 312, 384
arrhythmias seecardiac dysrhythmias
artemether 364
artenusate 364
Arthus reactions 66, 400
arylaminoalcohols 363
ascariasis, drugs for 366
ascites 40
ascorbic acid seevitamin C
aspergillosis, drugs for 340
aspirin 157–8
antacids and 249
asthma 157, 243
children and 54
ischaemic heart disease 65, 198, 199, 200,
201–2, 208
migraine 142
nicotinic acid and 183
poisoning 448
thyroid crisis and 295
warfarin and 208
asthma 233–5, 236–41
-adrenoceptor antagonists 190
adverse effects of drugs 243
aspirin 157, 243
cough 55
non-steroidal anti-inflammatory drugs and
168–9, 243
asystole 221
ataxiaseecerebellar ataxia
atazanavir 356
atenolol 224
birth weight 45
atheroma 177–84
diabetes mellitus 286
atopic dermatitis 413
atorvastatin 180
atovaquone
malaria prophylaxis 362
Pneumocystis carinii 358
zidovudine and 354
ATP binding cassette proteins (ABC proteins)
82
atracurium 150, 151452 INDEX