atrial fibrillation 217, 221
digoxin 215
atrial flutter 217, 221
atrioventricular block 217, 223
atropine 226–7
cardiopulmonary resuscitation 221
for iridocyclitis 425
in Lomotil 258
as mydriatic 425
atypical antipsychotic drugs 113–14
azathioprine 402
allopurinol and 173
on liver 262
myasthenia gravis 130
azelaic acid 411
azithromycin 328, 329
azoles 341–3, 350
ciclosporin and 350, 402
aztreonam 327
phase 15
bacteria
chronic obstructive pulmonary disease 236
gastrointestinal tract
drug absorption and 20
drug metabolism 29
infections, treatment algorithm 324
resistance to antibiotics 324–5
bactericidalvsbacteriostatic agents 323
balsalazide 255
barbiturates 442
Barker hypothesis 185
Bartter’s syndrome 258, 278
basic drugs, renal reabsorption 32
basic life support 219–20
basiliximab 404
BCNU, bone marrow suppression 370
beclometasone 240
behavioural emergencies 114–15
bendroflumethiazide 5, 59, 192, 258, 275, 315
benoxaprofen 64–5
benzalkonium chloride 238
benzocaine 154
benzodiazepines 108–9
active metabolites 14
alcohol withdrawal 441
in anaesthesia 149
as anti-emetics 255
as anticonvulsants 137–8
azoles and 350
elderly patients 57
liver disease 261
benzoyl peroxide 411
benzylpenicillin 326
beriberi 266
beta-blockerssee-adrenoceptor antagonists
betahistine 254
bevacizumab 383 , 428
bezafibrate 181 , 182, 183
bicalutamide 384
bicarbonate
plasma levels, acetazolamide on 274–5
see alsosodium bicarbonate
biliary obstruction, anion-exchange resins for
182
binding
receptors 6
tissues, drug displacement 73
see alsoprotein binding
bioavailability 17–18
grapefruit juice on 408
bioequivalence, drug formulations 18, 90
biological immunosuppressants 403–4
biological response modifiers 384–5
biotechnology 92
birth weight 45
bismuth chelate 251
bisphosphonates 299–300
iron absorption 389
black triangle scheme 64–5, 90
bladder, drugs for 279
blastomycosis (North American), drugs for 340
bleomycin 378
interstitial pneumonitis 385
blood–brain barrier
children 52
fetus 45
renal failure 36
blood flow
intramuscular injection and 21
kidney, renal failure 37
liver, drugs on 29
placenta 45
pulmonary, anaesthesia 146
blood pressure, combined oral contraceptives
309
blood:gas solubility coefficient, anaesthetics 145
body surface area, normalization of glomerular
filtration rate 57
bolus doses, pharmacokinetics 12–13
bone
foscarnet binding 346
metabolic diseases 297
pain, terminal care 163
bone marrow
cytotoxic drugs on 370–1
methotrexate on 374
penicillamine on 171
zidovudine on 353
boosted protease inhibitor therapy 356, 360
bortezomib 382
Boston Collaborative Drug Surveillance Program
65
botanical medicines 97
botulinum toxins 129
bradycardias 217, 223
bradykinin 187, 189
brand names seeproprietary products
breast carcinoma
hormone replacement therapy and 311
hormone therapy for 383, 384
breast-feeding 53–4
antithyroid drugs 295
fluconazole 342
warfarin 209
brimonidine 426
bromhexine 242
bromocriptine 312, 315
bronchiolitis, ribavirin 347
bronchitis 235–6
bronchodilators 233, 236, 238
buccal route 20
budesonide
inflammatory bowel disease 255
inhaled 240
bulk agents 256, 257, 264
for diarrhoea 258
bull’s-eye macula 362
bupivacaine 153
buprenorphine 162
bupropion 439
buserelin 317, 318
buspirone 109
busulfan 372
butyl nitrate 442
C-peptide 285
cabergoline 312
Cafergot 144
caffeine 439
malignant hyperthermia 84
neonates, theophylline metabolite 42supraventricular tachycardia 229
-calcidol 298
calciferol 298
calcification 87–9
calcineurin inhibitors 401–2
see alsociclosporin
calcipotriol, psoriasis 414
calcitonin 299, 300
calcitriol 297, 298
calcium 297
supplements 298–9
tetracyclines on absorption 329
calcium carbonate 250
calcium-channel blockers 191–2
azoles and 350
ciclosporin and 402
ischaemic heart disease 198, 201
calcium chloride 227
calcium gluconate 279
calculi (biliary) seegallstones
calculi (urinary), prevention with thiazides 276
calories, thiamine dosage calculation 266
camptothecins 378
cancerseemalignant disease
candesartan 188–9
candidiasis
drugs for 340 , 416
HIV infection 359
inhaled glucocorticoids 239
cannabinoids 254–5
rimonabant 263
cannabis 437
capecitabine 376
capreomycin 338
capsaicin 155
captopril
hepatotoxicity 263
hyperkalaemia 280
sulphhydryl group effects 188
carbamazepine 135
action mechanism 133
cross-sensitivity, phenytoin 136
erythromycin and 141
SIADH 277
carbapenem 332
carbimazole 293–4
carbon monoxide 449, 450
carbonic anhydrase inhibitors 274–5
glaucoma 426
carboplatin 374
carboprost 313
carboxypeptidase-G2 374
carcinoma seebreast carcinoma; malignant
disease; prostate carcinoma
cardiac afterload 212
cardiac arrest 218–21
bupivacaine 153
from potassium supplements 278
thiopental 148
cardiac compression 220
cardiac dysrhythmias 217–29
pimozide 350
poisoning 446
tricyclic antidepressants 448
see alsoatrial fibrillation
cardiac failure seeheart failure
cardiac output 186
cardiac preload 212
cardiac valve prostheses, anticoagulants in
pregnancy 50
cardiomyopathy, anthracyclines 378
cardiopulmonary resuscitation 218–21
cardioselective -adrenoceptor antagonists 190
cardiotoxicity, anthracyclines 377–8
cardioversion 221
carotene 265INDEX 453