carteolol 429
carvedilol 214
case-control studies, adverse drug reactions 65
caspofungin 343–4
catecholO-methyltransferase inhibitors 125
catecholamines, metabolism 27
cavernosal injection, alprostadil 315
CD4 receptor, HIV infection 351
CD41 T-cells 400
cefalexin, cystic fibrosis 34
cefotaxime 327
ceftazidime 327
ceftriaxone 327
cefuroxime 327
celiprolol 214
cell-based therapies 92–6
cell cycle, phase specificity of cytotoxic drugs
368, 369
cellular immunity 399
central nervous system
elderly patients 58
fetus 45
central pontine myelinolysis 277
cephalosporins 327
cerebellar ataxia 129
5-fluorouracil 376
cetirizine 241, 405 , 406
cetuximab 383
charcoal, activated 445, 446
chelating agents, of metals 10
chemokine receptors, HIV infection 351
chemoreceptor trigger zone (CTZ) 253
chemotherapy, malignant disease 367–85
see alsocytotoxic drugs
children 52–5
cycloplegia 425
hypnotics 107
iron preparations 390
tetracyclines and 329
chimeric antibodies 382
chloralseecloral
chlorambucil 372
bone marrow suppression 370
chloramphenicol 328
aplastic anaemia 328, 395
bacterial resistance 325
eye 427
2-chlorodeoxy adenosine 377
chloroprocaine 154
chloroquine
acute malaria 362–3
G6PD deficiency 366
malaria prophylaxis 362
rheumatoid arthritis 170
chlorphenamine 405
anaphylactic shock 405
chlorpromazine 112–13
hepatotoxicity 263
chlorpropamide 289
alcohol and 442
elderly patients and 59
chlortalidone 191, 192
chlortetracycline, eye 427
cholecalciferol 297
cholecystokinin 263
cholesterol 177–8
diuretics 192
see alsofamilial hypercholesterolaemia
cholestyramineseecolestyramine
cholinergic crisis 130–1
cholinergic receptors, eye 424
cholinesterase 25
chondroitin 101
chorea (Huntington’s disease) 129
chorionic gonadotrophin 312
chronic obstructive pulmonary disease 235–6
-adrenoceptor antagonists 190
glucocorticoids 236, 239
chronic viral hepatitis 261
chronotropes, negative 212
ciclosporin 401–2
azoles and 350, 402
on caspofungin 343
glucocorticoid requirement reduction 241
inflammatory bowel disease 256
plasma concentration monitoring 43
psoriasis 414
seizures 408
cidofovir 347
cilastatin 327
ciliary body 423
cimetidine 249–50, 251
ciclosporin and 402
theophylline and 239
warfarin and 208, 252
cinacalcet 300
cinchonism 363
cinnarizine 254
ciprofloxacin 331
for diarrhoea 259
eye 427
cirrhosis 274
cisatracurium 151
cisplatin 373–4
methotrexate and 375
citric acid 279
cladribine 377
clarithromycin 328, 329
clearance of creatinine, nomogram 36
clearance of drugs 11–12, 13, 31
liver disease 38
see alsoelimination of drugs
clindamycin,Pneumocystis carinii 358
clinical trials 5, 64, 86–8, 89–90
clofazimine 339
clofibrate 182
clomethiazole 109, 442
clomifene 312
clonazepam 137–8
clonidine 150
clopidogrel 209
ischaemic heart disease 198, 199
cloral (chloral) 109, 442
Clostridium difficile 259
clotrimazole 342
clotting factors 92, 394–5
clozapine 110, 113
co-amoxiclav 326
co-proxamol, overdose 448–9
co-trimoxazole 330
ganciclovir and 347
Pneumocystis carinii 357
teratogenesis 51
coagulation cascade 204–5
coagulation factors 92, 394–5
cocaine 153, 438
on fetus 50
coccidioidomycosis
drugs for 340
HIV infection 359
codeine 162, 242
as antimotility drug 256, 258
colchicine 172
colestyramine 181 , 182
inflammatory bowel disease 256
colfosceril palmitate 242
collagens, glucosamine and 101
colloid infusion 277
combination therapy 72
anti-emetic 370
antibacterial 325with cytotoxic chemotherapy 371
highly active antiretroviral therapy 352–3
malignant disease 369
nucleoside analogue reverse transcriptase
inhibitors 353
for Parkinson’s syndrome 125
tuberculosis 72, 335–6, 338
combined oral contraceptives 308–10, 311, 315
common cold, echinacea and 99
competitive antagonists 8, 9 , 10
on effect of partial agonists 9
complementary medicines 97–102
compliance
antituberculous therapy 336
elderly patients 58
concentrations of drugs
constant-rate infusion 11
dissociation equilibrium constant 9
monitoring 41–4
in overdose 445
paracetamol overdose 447
repeated dosing 14
vsresponse to drugs 6
single-bolus dose 12
confidence intervals 89
confusion (mental), H 2 -receptor antagonists 251
conjugation 24, 25–7
Conn’s syndrome 305
constant-rate infusion, pharmacokinetics 11–12
constipation 256–8
liver disease 38
contact dermatitis 66–7, 413, 417
contact lenses, drug-induced problems 429
contraceptives (hormonal) 308–11
anticonvulsants and 139
antituberculous drugs and 339
combined oral 308–10, 311, 315
on fetus 50
post-coital 310
progestogens 308
contrast media, X-rays, reactions 404
controlled drugs 436–7
controls, clinical trials 88
copper 269
coronary artery bypass grafting 197–8, 200
coronary syndrome, acute 198, 199
see alsomyocardial infarction
corticosteroids
children 54
interaction with anticonvulsants 74
occlusion on skin absorption 20, 22
on phenylethanolamine N-methyltransferase
27
pregnancy 50
see alsoglucocorticoids
cough 242
ACEIs 188
asthma 55
COX-2 inhibitors, selective 167, 169
crack cocaine 438
creatine phosphokinase, intramuscular injections
and 21
creatinine, serum levels
elderly patients 57
renal failure 36
Crigler–Najjar syndrome 27
criminal poisoning 449
Crohn’s disease 255, 256
drug disposition 34
cromoglicate 405
asthma 239–40
eye 428
hay fever 406
cross-tolerance 433
crossover design, clinical trials 88
cryptococcosis 340 , 359454 INDEX