5-fluorouracil 375–6
fluoxetine, monoamine oxidase inhibitors and
118
flutamide 384
fluticasone 240
folate 392
antagonism in malaria treatment 364
deficiency 268, 269, 392
Toxoplasma gondii 358
vitamin B 12 deficiency 391
see alsoantifolate analogues
folinic acid
methotrexate antagonism 374, 375
methotrexate concentrations requiring 42
follicle-stimulating hormone 307, 312, 317
fomiversen 95
fondaparinux 206
food
drug absorption and 19
on first-pass metabolism 29
formularies 4
formulations of drugs
bioequivalence 18, 90
elderly patients 60
see alsoliquid preparations
fosamprenavir 356
foscarnet 346
cytomegalovirus 359
eye 427
fosphenytoin 136, 137
framycetin, eye 427
free-radical hypothesis, Parkinson’s syndrome
124
fulvestrant 312, 384
fungi 340
drugs against 340–4
HIV infection 359
skin infections 416
furosemide 275
methotrexate and 375
pulmonary oedema 213
fusidic acid 329
eye 427
on liver 262
fusion inhibitors (HIV) 357
G-protein-linked receptors 7
desensitization 9
G6PD deficiency seeglucose 6-phosphate
dehydrogenase deficiency
GABA (-aminobutyric acid) 133
gabapentin 138
galantamine 131–2
gallstones
drug-induced 69
octreotide 317
ganciclovir 346–7
cytomegalovirus infection 359
eye 427
garlic 97–8
gastrectomy
partial, iron absorption 389
vitamin B 12 deficiency 391
gastric emptying seestomach, emptying
gastric haemorrhage 252
aspirin 157
gastric lavage 445
gastric ulcers, endoscopy 249
gastrin 247
gastro-oesophageal reflux, pregnancy 49
gastrointestinal tract 247–59
bacteria
drug absorption and 20
drug metabolism 29
‘dialysis’ 446
diseases on drug disposition 34
drug metabolism 28, 29
iron preparations on 390
kidney disease on 35
pharmacokinetics 19–20
gate mechanisms, pain 155
Gaucher’s disease, biotechnology 92
gefitinib 381
gemcitabine 377
gemeprost 311
gemfibrozil 181 , 182, 183
gemtuzumab 383
gene therapy 92, 94–5, 96
general anaesthetics 145–54
inhalational 145–8
intravenous 148–9
generalized seizures, drugs for 134
generic drugs 90
prescribing 17–18
genetic variations, first-pass metabolism 29
genistein 100
genital herpes, aciclovir 345
gentamicin 328
eye 427
methotrexate and 375
plasma concentration monitoring 42
geriatrics, polypharmacy (case) 5
germ-line gene therapy 94
GHB (-hydroxybutyric acid) 442
giant-cell arteritis, prednisolone 169
Giardia lamblia, drugs for 365
Gilbert’s disease 84
ginkgo biloba 99
ginseng 98–9
glargine insulin 286
glaucoma
acetazolamide 274
from anticholinergic agents 238
drugs for 425–6
mydriatics and 425
osmotic diuretics 276
glibenclamide 289
elderly patients and 59
gliclazide 289
glitazones 289–90
globalization, drug development 91
glomerular filtration 31
ACEIs 188
children 53
estimated rate 57
heart failure 35
pregnancy 47
renal failure 36
thyroid disease 39
glomerulonephritis, immune-complex,
penicillamine 171
glucagon 288
glucan, echinocandins on synthesis 343
glucocorticoids 169, 302–5
for allergic disease 405
as anti-emetics 255
asthma 239
chronic obstructive pulmonary disease 236,
239
dermatitis 413–14
eye 427
hay fever 406
idiopathic thrombocytopenic purpura 395
immunosuppression 400–1
inflammatory bowel disease 255
inhaled 234, 239
for malignant disease 384
requirement reduction 241
thyroid disease 39
see alsocorticosteroids; hydrocortisone;
prednisolone
glucosamine 101glucose 6-phosphate dehydrogenase deficiency
68–9, 81 , 83, 331, 366
glucuronidation 25–7
neonates 28
glutamate 133
glutathione 27, 260
glycerol suppositories 257
glyceryl trinitrate 196–7, 198, 200–1
glycoprotein IIb/IIIa, inhibitors 209
glycylxylidide 223
gold salts 170–1
gonadotrophin-releasing hormone 307
analogues 317–18, 384
gonadotrophins 307, 312, 317
Good Clinical Practice 87
goserelin 312, 317, 318, 384
gout 171–3
granulocyte colony-stimulating factor 394
grapefruit juice 408
Graves’ ophthalmopathy 295
grey baby syndrome, chloramphenicol 328
griseofulvin 344
on spermatozoa 46
growth hormone 316–17
recombinant 92, 316
gynaecomastia, cimetidine 250
H 1 -receptors 404
antagonistsseeantihistamines
H 2 -receptor antagonists 249–51
elderly patients 60
pancreatic enzyme replacement and 250,
259
H 2 -receptors 404
H 3 -receptors 404
haematinicsseefolate; iron; vitamin B 12
haematopoietic growth factors 370, 379, 392–4
haemodynamics, nitrates 201
haemolytic anaemia
adverse drug reactions 68–9
antibiotics 331
methaemoglobinaemia 83
haemolytic disease of the newborn 400
haemophilias 394–5
desmopressin 278, 395
haemorrhage
gastric 252
aspirin 157
liver disease 260
oesophageal varices 261
half-life, drug concentration 12, 13
heparin 206
liver disease 38
repeated dosing and 14
two-compartment models 15
halibut liver oil 265–6
hallucinogens 437
halofantrine 363
haloperidol 112, 114
halothane 146, 147
haptens 400
hay fever 405, 406
heart
anthracyclines on 377–8
see also entries beginningcardiac...
heart failure 211–16
-adrenoceptor antagonists 190, 214
pharmacokinetics 34–5
Helicobacter pylori 247–8, 249
helminthic infections 364–6
heparins 205–6
pregnancy 50, 209
hepatic encephalopathy 260–2
hepatitis, viral 348–9
chronic 261
hepatitis B virus 261INDEX 457