hepatotoxicity 69, 262, 263
halothane 146, 147
non-steroidal anti-inflammatory drugs 169
rifampicin 336
see alsoparacetamol
hepcidin 389
herbal medicines 97–102
heroin (diamorphine) 161, 434, 435, 442
herpes simplex virus infection
aciclovir 345
HIV infection 359
skin 417
high-density lipoprotein (HDL) 179
highly active antiretroviral therapy (HAART)
352–3
hirsutism 412
hirudin 206–7
histamine 404–5
atracurium causing release 151
histone deacetylase inhibitors 382
histoplasmosis
drugs for 340
HIV infection 359
historical aspects 86
opioids 159
history-taking 4
adverse drug reactions 63
HIV infection 351–60
tuberculosis 338, 359
see alsoanti-HIV drugs
HMG CoA reductase inhibitors seestatins
hoarseness, inhaled glucocorticoids 239
Hoffmann elimination, atracurium 151
homeopathic medicines 97
hookworm, drugs for 365
hormone replacement therapy (HRT) 311–12, 315
progestogens in 308, 312
hormones
for acne 411
for malignant disease 383–4
human normal immunoglobulin 407–8
humanization
antibodies 382
recombinant proteins 93
humoral immunity 399
Huntington’s disease 129
hydatid disease, drugs for 365
hydralazine 194
nitrates with 214
slow acetylators 81, 82
hydration, skin 20
hydrocortisone 303–4
anaphylactic shock 405
asthma 239
G6PD deficiency and 83
respiratory failure 242
hydrolysis of drugs 25
-hydroxybutyric acid (GHB) 442
hydroxychloroquine, rheumatoid arthritis 170
hydroxyphenyl amines 260
5-hydroxytryptamine
migraine 142
mood disorders and 116
syndrome 118
see alsoserotonin-only hypothesis
5-hydroxytryptamine 1 agonists, migraine 142–3
5-hydroxytryptamine 3 receptor antagonists 254
hydroxyurea 377
hyoscine 253
hypercalcaemia 299
diuretics 192
hyperkalaemia 278–9, 280
ACEIs 188
calcium chloride in 227
treatment of heart failure 213
hyperosmolar non-ketotic coma 288
hypersensitivity reactions 399–400
delayed 66–7, 400
glucocorticoids for 400
with histamine release 404–5
vaccine preparations 407
hypertension 185–95
alcoholism 440
diabetes mellitus 286
erythropoietin 396
pregnancy 50
see alsoantihypertensive drugs
hypertensive crises, monoamine oxidase
inhibitors 120, 123
hyperthermia, malignant 80 , 83–4, 152
hyperthyroidism 292, 293–5
pharmacokinetics 38–9
hyperuricaemia 171–3
hypnotics 105–7, 108, 109
elderly patients 58, 107
hypocalcaemia 300
hypoglycaemia 288
-adrenoceptor antagonists 190, 214, 224
alcohol 442
hypogonadism, male 313
hypokalaemia 278
diuretics 192, 275
drug-induced 69
elderly patients 59
heart failure 213
liver disease 38, 40
hyponatraemia
antidepressants 118, 122
SIADH 277
hypopituitarism, hypothyroidism in 293
hypotension
ACEIs 213
poisoning 446
postural 57–8
streptokinase 202
hypothermia 220
hypothyroidism 293
pharmacokinetics 38–9
hypovolaemia 277–8
hypoxia, nitrous oxide 147
hypoxia-inducible factor-1 (HIF) 393
ibuprofen 158
idiopathic thrombocytopenic purpura 395
idiosyncratic drug reactions 62
idoxuridine, eye 427
ifosfamide 372
imatinib 380–1
imidazoles 341–2
imipenem 327
immune-complex glomerulonephritis,
penicillamine 171
immune-complex reactions 66, 400
immune responses 399
mediators and blockers 404–6
immunoglobulins (therapeutic) 93, 407–8
immunopharmacology 399–408
immunostimulants 407
immunosuppressive drugs 399, 400–4
inflammatory bowel disease 256
myasthenia gravis 130
plasma concentration monitoring 43
rheumatoid arthritis 170
impotenceseeerectile dysfunction
inclusion criteria, clinical trials 88
incontinence 279
indinavir 356
indometacin 169
on ductus arteriosus 46, 313
induction of enzymes 27–8, 76
anticonvulsants 137
infectionsalcoholism 440
bacterial, treatment algorithm 324
carbimazole 294
cytotoxic chemotherapy 371
diabetes mellitus 287
eye 427
immunosuppression 400
mycobacterial 334–9
opioid addiction 435
parasites 361–6
skin 416–17
streptococcal, streptokinase and 202
viral 344
hepatitis 261, 348–9
skin 417
see alsoanti-HIV drugs; antiviral agents; HIV
infection
see alsoantibiotics; fungi; urinary tract, infections
infective endocarditis, prophylaxis with
antibiotics 325
infertility
cytotoxic drugs 371
drugs for 312
immunosuppressive drugs 400
inflammation 167
inflammatory bowel disease 255–6
infliximab
Crohn’s disease 256
immune diseases 171, 404
psoriasis 415
influenza, antiviral agents for 348
infusion, pharmacokinetics 11–12
inhalational anaesthetics 145–8
inhalers
asthma 234
children 54
drug absorption from 21
glucocorticoids 239
asthma 234
insulin via 288
salbutamol 237
inhibition, enzymes 28
inhibitors, receptors 7
injection site reactions, enfuvirtide 357
inotropes, positive 212
insomnia 105–7
insulin(s) 286–8
‘designer’ 92–3, 286
elderly patients 59
physiology 285
intensive care, sedation 150
intensive monitoring, adverse drug reactions 65
interferon-alfa 2b 385
interferons 348–9
theophylline and 239
viral hepatitis 261
interleukin-2 384, 407
interleukin-11 394
international normalized ratio (INR) 207
paracetamol overdose 447
interstitial nephritis, drug-induced 69, 70, 168
interstitial pneumonitis, bleomycin 385
intra-ocular pressure 425
see alsoglaucoma
intra-uterine devices 310
intracranial pressure
halothane and 146
osmotic diuretics 276
intramuscular injection 21
intranuclear receptors 7
intrathecal route 22
baclofen 128
methotrexate 375
morphine 160
intravenous route 22
anaesthetics 148–9458 INDEX