children 54
diazepam 108
iron preparations 390–1
phenytoin 137
intrinsic factor 391–2
iodine 292–3
radioactive 294–5
ion-exchange resins 279
ipratropium 237–8
hay fever 406
irinotecan 378
iris 423
iron 389–91
deficiency 389–90
pregnancy 392
preparations 390–1
tetracyclines on absorption 329, 389
iron dextran 391
iron sucrose 391
irreversible binding 6
irritable bowel syndrome 259
ischaemic heart disease 196–203
aspirin 65, 198, 199, 200, 201–2
isoflurane 146–7
isoniazid 335, 336
acetylation 80–1
hepatotoxicity 263
peripheral neuropathy 267
isosorbide mononitrate 200
isotretinoin 412
itraconazole 342–3
jaundice
chlorpromazine 112
Crigler–Najjar syndrome 27
jet lag 107
joints, injection of glucocorticoids 169
kanamycin 338
kernicterus 52, 73
aspirin 158
ketamine 149
ketoacidosis 287
ketoconazole 342, 384
ciclosporin and 402
ketotifen, confusion with ketoprofen 243
kidney
adverse drug reactions 69
aminoglycosides on 328
amphotericin on 341
cephalosporins 327
cisplatin 373
disease on pharmacokinetics 35–7
diuretics, sites of action 274
drug elimination 31–3
children 53
elderly patients 57
heart failure 35
lithium 122
pregnancy 47
renal failure 36–7
foscarnet on 346
hypertension 186
methotrexate 375
non-steroidal anti-inflammatory drugs on 168
transplantation, interaction of anticonvulsants
and corticosteroids 74
triazole diluent on 343
Korsakoff’s psychosis 440
lacrimal gland 423
-lactam antibiotics 325–7
-lactamase inhibitors 326
-lactamase-resistant penicillins 326
lactate solution, Ringer’s 277
lactation, suppression 312
lactic acidosis, metformin 289
lactulose 257, 260
lamivudine 349, 354
viral hepatitis 261
lamotrigine 133, 138
lanosterol 14- -demethylase (fungal) 341
lanreotide 316
lansoprazole 251
latanoprost 426
laxatives 256–8
abuse 257–8
pregnancy and 49
leishmania infections, drugs for 365
Lennox–Gastaut syndrome 138
lenograstim 394
leprosy 339
leptin 262–3
leucovorinseefolinic acid
leukopenia, antithyroid drugs 294
leukotriene receptor antagonists, asthma 235, 240
leukotrienes 240
leuprolide 384
leuprorelin 317
levamisole 385
levodopa 124–6
free-radical hypothesis 124
levonorgestrel 310
lice 417
lichenoid eruptions, drugs causing 418
lidocaine 153
-adrenoceptor antagonists and 191, 224
as antidysrhythmic drug 222, 223
pharmacokinetics in heart failure 35
linezolid 332
lipid-solubility of drugs 11
elderly patients 57
inhalational anaesthetics 146
renal clearance and 31
volume of distribution and 13
lipids 177–9
lipodystrophy 288
lipoproteins
high-density (HDL) 179
low-density, diuretics 192
pathways 178
liposomal amphotericin 341
5’-lipoxygenase inhibitors 240–1
liquid preparations, oral route 52, 54
lispro insulin 92–3, 286
literature on drugs 5
lithium 121–2
depression 117
diuretics and 192
loop diuretics and 275
non-steroidal anti-inflammatory drugs and 168
plasma concentration monitoring 42
liver
blood flow, drugs on 29
drug metabolism 24–5
children 53
elderly patients 57
heart failure 35
methotrexate 375
pregnancy 47
see alsohepatotoxicity
liver disease 260–2
albumin 37–8, 274
cirrhosis 274
drug-induced 262, 263
first-pass metabolism 29
on pharmacokinetics 37–8, 40
liver flukes, drug for 366
loading doses 12, 14
digoxin 14
renal failure 36
local anaesthesia 152–4extradural route 22
eye 428
lofepramine 120
lofexidine 436
logarithmic dose–response curves 8
Lomotil 258
loop diuretics 275
heart failure 213
loperamide 256, 258
lopinavir 356, 360
loratadine 241, 405 , 406
lorazepam 108, 114, 139
low-density lipoprotein, diuretics 192
low-molecular-weight heparins (LMWH) 205–6
pregnancy 209
Lown–Ganong–Levine syndrome 218
lubricant laxatives 257
Lugol’s iodine solution 293
lungs, adverse effects of drugs 243
lupus erythematosus
drugs causing 418
systemic, drug-induced 69
luteinizing hormone 307, 312, 317
lymphadenopathy, adverse drug reactions 68
lymphocytes, adverse drug reactions 63
lysergic acid diethylamide (LSD) 437
MABEL (minimum anticipated biological effect
level) 93, 94
macrogols 257
macrolides 328–9
see alsoamphotericin
macula
age-related degeneration 428
bull’s-eye 362
magnesium deficiency, hyperosmolar non-ketotic
coma 288
magnesium salts
as antacids 250
chloride 221, 227–8
sulphate 227
as laxative 257
trisilicate, iron absorption 389
maintenance doses 12
malaria 361–4
G6PD deficiency and 366
pregnancy 48
relapse 364
malignant disease
from chemotherapy 371
chemotherapy for 367–85
see alsocytotoxic drugs
combined oral contraceptives 309
erythropoietin and 393
fibrates and 182
from immunosuppressive drugs 400
oestrogens 308, 384
malignant hyperthermia 80 , 83–4, 152
malignant neuroleptic syndrome 112
Mallory–Weiss syndrome 440
mania 114–15, 116
mannitol 276, 426
maprotiline 119
mebeverine 259
mechlorethamine 372
Medicines and Health Care Regulation Agency
(MHRA) 86
medroxyprogesterone acetate 308, 310
mefloquine 362, 363
melatonin 107
melphalan 372
bone marrow suppression 370
memantine 131, 132
membrane permeability 11
menopause, hormone replacement therapy 311,
315INDEX 459