sodium
ketoacidosis 287
laxative abuse 258
lithium and 122
liver disease 38
see alsovolume overload
sodium bicarbonate
as antacid 250
aspirin poisoning 448
calcium chloride and 227
ketoacidosis 287
magnesium salts and 228
tricyclic antidepressant poisoning 448
urine alkalinization 279
sodium fusidate seefusidic acid
Na–KATPase, digoxin on 215, 226
sodium valproate 135
migraine prophylaxis 143
solifenacin 279
solubility
anaesthetics 145
see alsolipid-solubility of drugs; water-
solubility of drugs
solvent abuse 442
somatomedin 316
somatostatin 316
oesophageal varices 261
somatropin 92, 316
Somogyi effect 288
sorafenib 382
sotalol 222, 225
soy 99–100
spasticity 128
specificity of drugs 6
spermatozoa
drugs on 46
storage before chemotherapy 371
spina bifida, anticonvulsants 49
spironolactone 40, 193, 214, 276, 305
splenectomy, idiopathic thrombocytopenic
purpura 395
sputum, viscosity reduction 242
St John’s wort 100–1, 102, 122
ST-segment-elevation myocardial infarction
198–200
staphylococci, antibiotic resistance 326
statins 180–2
azoles and 350
familial hypercholesterolaemia 83
ischaemic heart disease 197
on liver 262
myocardial infarction 200
statistics, clinical trials 88–9
status epilepticus 136, 139, 140
stavudine 354
steady-state concentrations 11
stem cell therapy 95–6
stents, coronary 197
Stevens Johnson syndrome 68, 419, 428
stilbestrol, on fetus 47
stimulant laxatives 257
Stokes–Adams attacks 217
stomach
acid secretion 247, 248
emptying 34
migraine 34, 142
neonates 52
pregnancy 47
renal disease on pH 35
see also entries beginninggastric...
stones
prevention with thiazides 276
see alsogallstones
streptococcal infections, streptokinase and 202
streptokinase 199, 202
streptomycin 335, 337–8
stress incontinence 279
stroke, hormone replacement therapy 311
Strongyloides stercoralis, drug for 365
strontium ranelate 300
subcutaneous route 21–2
sublingual route 20
substance abuse 433–43
sucralfate 252
suicide genes 94, 95
sulfadiazine,Toxoplasma gondii 358
sulfamethoxazole, pregnancy 51
sulfasalazine 19, 170 , 255
sulfinpyrazone 173
sulindac 37, 168
sulphation 27
sulphhydryl group effects, ACEIs 188
sulphonamides 330
kernicterus 73
methotrexate and 330, 375
sulphonylureas 289
SIADH 277
sulphonamides and 330
sulphoxidation 81
sumatriptan 142–3
sunitinib 382
supersensitivity 10
supportive therapy
self-poisoning 445–6
see alsoresuscitation
supraventricular dysrhythmias 217–18, 221–2,
229
surfactants, pulmonary 242
surrogate markers 41
surveillance, adverse drug reactions 63–6
sustained-release preparations seeslow-release
preparations
suxamethonium 150–1, 152
pentamidine and 358
sensitivity 80 , 81–2, 152
syndrome of inappropriate antidiuretic hormone
(SIADH) 276–7
synergy 72
syntometrine 313
systemic absorption
eye 423, 425 , 426
nose 21
skin 20–1, 22, 52, 54, 414
systemic lupus erythematosus, drug-induced
69
systolic hypertension, elderly patients 195
T-lymphocytes, transplantation 95
tachycardia–bradycardia syndrome 223
tachycardias 217, 221–3
supraventricular 217–18, 221–2, 229
ventricular 218, 222–3
tacrolimus 402
Taeniaspp., drugs for 365
tamoxifen 312, 384
genistein on 100
tamsulosin 280
tapeworms, drugs for 365
tardive dyskinesia 112
taxanes 379–80
tears 423
teicoplanin 330
telithromycin 332
hepatotoxicity 263
telomeres 367
temazepam 108, 150
tenecteplase 199, 202
teniposide 379
tenofovir 354
teratogenesis 46–7, 55
aciclovir 345
anticonvulsants 49
carbimazole 294
co-trimoxazole 51cytotoxic drugs 371
detection 48
immunosuppressive drugs 400
retinoids 412, 416
ribavirin 347
vitamin A 266
warfarin 50
terbinafine 343
terbutaline 237
teriparatide 300
terlipressin, oesophageal varices 261
terminal disease, analgesics 162–3
testosterone 313–14
tetrabenazine 129
tetracaine 154
tetracosactide 318
tetracyclines 329
acitretin and 416
acne 411
eye 427
iron absorption 329, 389
on liver 262
thalidomide 46, 64, 86, 385
theophylline 238–9
adenosine and 226
ciprofloxacin and 331
pharmacokinetics in heart failure 35
plasma concentration monitoring 42, 43
therapeutic drug monitoring 41–4
anticonvulsants 134–5
digoxin 215
lithium 121
pregnancy 49
therapeutic index 41
thiacetazone 338
thiamine (vitamin B 1 ) 266
thiazides 192, 275–6
see alsobendroflumethiazide
thiazolidinediones 289–90
thiopental 148, 442
thiopurine-S-methyltransferase 79, 84, 376
threadworm, drugs for 365
thrombocytopenia
adverse drug reactions 68
idiopathic 395
thromboembolism
combined oral contraceptives 309
hormone replacement therapy 311
thrombolytic therapy (fibrinolytics), ischaemic
heart disease 199, 202–3
thrombopoietin 394
thrombosis 204–5
thromboxane A 2 208
thymectomy, myasthenia gravis 130
thyroid crisis 295
thyroid gland 292–6
amiodarone 224
disease on pharmacokinetics 38–9
drugs affecting 295
thyroid stimulating hormone 292
thyroxine 293
thyroid disease 39
weight reduction 264
tiaconazole 342
tiagabine 138
tibolone 312
tics 129
time to peak plasma concentration (Tmax)18
tinea 416
tiotropium 238
tipranavir 356
tissue binding, drug displacement 73
tissue to plasma concentration ratios 41–2
tobramycin 328
tocopherol (vitamin E) 268
tolbutamide 289
see also CYP2C9polymorphism464 INDEX