A Textbook of Clinical Pharmacology and Therapeutics

CONTENTS

FOREWORD viii

PREFACE ix

• PART I GENERAL PRINCIPLES ACKNOWLEDGEMENTS x
  
  
  • 1 Introduction to therapeutics
  
  
  • 2 Mechanisms of drug action (pharmacodynamics)
  
  
  • 3 Pharmacokinetics
  
  
  • 4 Drug absorption and routes of administration
  
  
  • 5 Drug metabolism
  
  
  • 6 Renal excretion of drugs
  
  
  • 7 Effects of disease on drug disposition
    
    
    • 8 Therapeutic drug monitoring
    
    
    • 9 Drugs in pregnancy
    
    
    
    
  
  
  • 10 Drugs in infants and children
  
  
  • 11 Drugs in the elderly
  
  
  • 12 Adverse drug reactions
  
  
  • 13 Drug interactions
  
  
  • 14 Pharmacogenetics
  
  
  • 15 Introduction of new drugs and clinical trials
  
  
  • 16 Cell-based and recombinant DNA therapies
    
    
    • nutraceuticals 17 Alternative medicines: herbals and
    
    
    
    
  
  
  
  


• PART II THE NERVOUS SYSTEM


• 18 Hypnotics and anxiolytics


• 19 Schizophrenia and behavioural emergencies


• 20 Mood disorders
  
  
  • disease 21 Movement disorders and degenerative CNS
  
  
  
  


• 22 Anti-epileptics


• 23 Migraine


• 24 Anaesthetics and muscle relaxants


• 25 Analgesics and the control of pain


• PART III THE MUSCULOSKELETAL SYSTEM
  
  
  • of arthritis 26 Anti-inflammatory drugs and the treatment
  
  
  
  


• PART IV THE CARDIOVASCULAR SYSTEM
  
  
  • cholesterol and other approaches 27 Prevention of atheroma: lowering plasma
  
  
  
  


• 28 Hypertension


• 29 Ischaemic heart disease


• 30 Anticoagulants and antiplatelet drugs
  
  
  • 31 Heart failure
  
  
  
  


• 32 Cardiac dysrhythmias
  
  
  • PART V THE RESPIRATORY SYSTEM
    
    
    • disease (COPD) and other respiratory disorders 33 Therapy of asthma, chronic obstructive pulmonary
    
    
    
    
  
  
  • PART VI THE ALIMENTARY SYSTEM
  
  
  • 34 Alimentary system and liver
  
  
  • 35 Vitamins and trace elements
  
  
  • PART VII FLUIDS AND ELECTROLYTES
  
  
  • 36 Nephrological and related aspects
  
  
  • PART VIII THE ENDOCRINE SYSTEM
  
  
  • 37 Diabetes mellitus
  
  
  • 38 Thyroid
  
  
  • 39 Calcium metabolism
  
  
  • 40 Adrenal hormones
  
  
  • 41 Reproductive endocrinology
  
  
  • 42 The pituitary hormones and related drugs
  
  
  • PART IX SELECTIVE TOXICITY
  
  
  • 43 Antibacterial drugs
  
  
  • 44 Mycobacterial infections
  
  
  • 45 Fungal and non-HIV viral infections
  
  
  • 46 HIV and AIDS
  
  
  • 47 Malaria and other parasitic infections
  
  
  • 48 Cancer chemotherapy
  
  
  • PART X HAEMATOLOGY
  
  
  • 49 Anaemia and other haematological disorders
  
  
  • PART XI IMMUNOPHARMACOLOGY
  
  
  • 50 Clinical immunopharmacology
  
  
  • PART XII THE SKIN
  
  
  • 51 Drugs and the skin
  
  
  • PART XIII THE EYE
  
  
  • 52 Drugs and the eye
  
  
  • PART XIV CLINICAL TOXICOLOGY
  
  
  • 53 Drugs and alcohol abuse
  
  
  • 54 Drug overdose and poisoning
  
  
  • INDEX