●^410 In elderly or debilitated patients:Anxiety Disorders and Anxiety Symptoms:Interactions● ALPRAZOLAMRoute and Dosage ● ● ● ● Panic Disorder:RifampinAdditive CNS depression with other sedative/hypnoticsniazid, ketoconazole, metoprolol, propoxyphene, propran-sequent toxicity can occur) with concurrent benzodiazepine Serum concentration of valerianolol, (e.g., therapy.Benzodiazepines may decrease the effitheophylline.Sedative effects of benzodiazepines may be decreased by Cimetidine, oral contraceptives, disulfi0.5 mg 3 times a day. Maximum daily dose 4 mg in divided 1 mg/day. dose at intervals of 3 to 4 days in increments of no more than Gradually increase if needed and tolerated. doses.^ ●^ oralcohol, other anxiolytics, opioid analgesics, PSYCHOTROPIC MEDICATIONS valproic acid ) may decrease the effi (Xanax) PO) and with : Initial dose: 0.5 mg 3 times a day. Increase may enhance effects of benzodiazepinesdigoxin 0.25 mg 2 or 3 times a day. herbal depressants cacy of benzodiazepines. may be increased (and sub- cacy of ram, flCNS depressants levodopa. uoxetine, iso- PO(e.g., : 0.25 to kava, and
2 2506_Ch25_406-416.indd Sec2:410 506 Ch 25 406 - 416 .indPreoperative Sedation:CHLORDIAZEPOXIDEMild to Moderate Anxiety:CLONAZEPAMSevere Anxiety:Elderly or Debilitated Patients:Seizures:Children (Acute Alcohol Withdrawal:d to exceed 20 mg.by 0.5 to 1 mg every 3 days. Total dailyneeded up to 300 mg/day. a day. centrations of clonazepam are 20 to 80 ng/ml.S0.1 to 0.2 mg/kg has been reached. 0.03 mg/kg/day (not to exceed 0.05 mg/kg/day) given in 2 or 3 equally divided doses; increase by no more than 0.25 a day.to 0.5 mg every third day until a daily maintenance dose of ec 2 : 410 ^ Adults:10 years or 30 kg):^ (Klonopin) PO^ PO^ (Librium) : 20 or 25 mg 3 or 4 times a day. : 0.5 mg three times a day. May increase^ PO: 5 to 10 mg 3 or 4 times a day.^ POPOPO: Initial daily dose 0.01 to : 5 or 10 mg 3 or 4 times : 50 to 100 mg; repeat as^ Therapeutic serum con-PO:^ maintenance dose not 5 mg 2 to 4 times^1 10/1/10 9:39:02 AM 0 / 1 / 10 9 : 39 : 02 AM
