Interactions● ● ● ● ● ● ● ● ● ● ● ● ● ● Increased risk of acute toxicity with Increased risk of suicidality in children and adolescents (black box warning) Nausea/vomiting Excessive sweatingIncreased effects of bupropion with Increased anticoagulant effect of clopidogrelAnorexia; weight lossrifampin(e.g., Decreased effects of bupropion with Increased effects of drugs metabolized by CYP2D6 isoenzyme psychiatric events (alcohol tolerance is reduced).cine, linezolid, Concomitant use with Seizures Headache cause hypertension.Coadministration with a fltion is contraindicated.Constipationzine, metoprolol, propafenone, uoxetine, sertraline, haloperidol, risperidone, thiorida-nortriptyline, imipramine, desipramine, paroxetine, , CYP2B6 inhibitors and ticlopidine alcoholnicotine replacement agent may produce adverse neuro-warfarinand (e.g., amantadine, levodopa, MAOIs. fl ecainidecimetidinecarbamazepine Antidepressants with bupropionCoadministra-) ), guanfa-● may^ and^429
2506_Ch26_417-446.indd 1429 2506 Ch 26 417 - 446 .indd Extended release tabs:BUPROPION 1 Depression (Wellbutrin):Seasonal Affective Disorder (Wellbutrin XL):Route and DosageSustained release tabs: 42 administered each morning beginning in the autumn prior to the target dose of 300 mg/day after 1 week. Therapy should the onset of depressive symptoms. Dose may be uptitrated to 100 mg 2 times a day. May increase after 3 days to 100 mg given 300 mg/day, given as a single daily dose in the morning. single daily dose in the morning. May increase after 3 days to 3 times a day. For patients who do not show improvement after between doses.ing. May increase to twice a day (total 300 mg), with 8 hours several weeks of dosing at 300 mg/day, an increase in dosage up with an interval of 4 to 6 hours between doses. should exceed 150 mg. To prevent the risk of seizures, administer to 450 mg/day may be considered. No single dose of bupropion 9 (Wellbutrin; Zyban) Begin dosing at 150 mg/day, given as aGive as a single 150 mg dose in the morn-^ PO: Adults (immediate release tabs):^ PO: 150 mg^1 10/1/10 9:39:22 AM 0 / 1 / 10 9 : 39 : 22 AM
