Mood-Stabilizing DrugsC HAPTER^27
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● ExamplesContraindicated in:Contraindications and Precautions: ● Action(Trade) NameLithium Generic Lithium citratealters sodium transport in nerve and muscle cells.on the reuptake of norepinephrine and serotonin. Effects on Not fully understood, but lithium may have an inflother neurotransmitters have also been noted. Lithium also Lithobid)carbonate (Eskalith; CHEMICAL CLASS: ANTIMANICD/20 –27(hrs) IndicationsHalf-life Category/Pregnancy ●●Unlabeled uses:●●●●●●● Cluster headaches Corticosteroid- Borderline personality Maintenance therapy Manic episodes Bulimia Neutropenia Postpartum affective Alcohol dependence(prophylaxis)psychosisbipolar disorderto prevent or diminish intensity of subse-quent manic episodesdisorderassociated with induced psychosis • Hypersensitivity • Severe cardio-Therapeutic Plasma Level Range mEq/LAcute mania: Maintenance: 0.6–1.2 1.0 –1.5 Available Syrup: 8 mEq Caps: 150, 300, Tabs (ER): 3 0 0, Tabs: 3 0 0 Forms (mg) (^450 600) 5 mLcarbonate)/to 300 mg equivalent (as citrate lithium uence
2506_Ch27_447-471.indd 0447 2506 Ch 27 447 - 471 .indd • Sodium depletion • Pregnancy and lactation 0 vascular or renal disease • Dehydrated or debilitated patients 447 1 10/1/10 9:39:39 AM 0 / 1 / 10 9 : 39 : 39 AM