● coma • Pyloric or duodenal obst● ● Adverse Reactions and Side EffectsContraindications and Precautions● • PregnancyAction● tatic hypertrophy • Bladder neckretention • Clients exposed to high environmental temperatures • Megacolon • Myasthenia gravis • Lactation • Children (● diphenhydramine) Use Cautiously in:• Hypertension • Hypotension • Tendency toward urinary Contraindicated in:of dopamine.Paralytic ileus Diphenhydramine also blocks histamine release by compet-ing with histamine for HConstipation Blocks acetylcholine receptors to diminish excess cholinergic Blurred vision response and somnolence are effected by diminished hista-mine activity. effects. May also inhibit the reuptake and storage of dopamine at central dopamine receptors, thereby prolonging the action Dry mouth • Tachycardia • Cardiac arrhythmias • Hypersensitivity • Angle-closure glau-^1 -receptor sites. Decreased allergic obstructions • Megaesophagus ruction • Peptic ulcers • Pros-Antiparkinsonian Agents ●except^503
2 2506_Ch29_502-510.indd Sec1:503 506 Ch 29 502 - 510 .indd Interactions● ● ● ● ● ● ● S● ● ● ● ● ● ● ● eAgitation, nervousness Anticholinergic drugs counteract the cholinergic effects of Urinary retention anticholinergic propertiesAdditive anticholinergic effects with other drugs that have Ta c h y c a r d i acIncreased effects of (Diphenhydramine):bethanechol.nervous systemDecreased sweating Elevated temperature Possible increased Orthostatic hypotensionExacerbation of psychoses Dizziness Sedation Nausea/vomiting 1 : 503 (CNS) depressants Additive sedative effects with digoxin beta-blockers levels with anticholinergicswith diphenhydraminecentral 1 10/1/10 9:40:25 AM 0 / 1 / 10 9 : 40 : 25 AM
