● ● ● ● Adverse Reactions and Side Effects● ● ● Interactions● ● ● ● ● ● ● ● ● ●^512 Drowsiness depressants Physical and psychological dependence Palpitations; tachycardia; hypotension To l e r a n c e Paradoxical excitement isoniazidDry mouth Lethargy Nausea and vomiting Confusion Blood dyscrasias Headache May aggravate symptoms in depressed persons Additive CNS depression with with Potentiates the effects of other central nervous system (CNS) Increased clearance and decreased half-life of benzodiazepines depressantsMore rapid onset or more prolonged benzodiazepine effect Decreased clearance and increased effects of benzodiazepines with with^ ●^ rifampinprobenecidcimetidine, oral contraceptives, disulfiPSYCHOTROPIC MEDICATIONSalcohol and other CNS ram, and
2 2506_Ch30_511-521.indd Sec2:512 506 Ch 30 511 - 521 .indHealthy elderly:ESTAZOLAMInsomnia:● Debilitated or small elderly patients: ● Route and Dosage FLURAZEPAM● Elderly or debilitated: Insomnia:Insomnia:QUAZEPAMElderly or debilitated: ● d theophyllineBenzodiazepines may increase serum levels of Decreased pharmacological effects of benzodiazepines with phenytoinIncreased benzodiazepine clearance with Increased bioavailability of triazolam with effective after 1 or 2 nights, may increase to 15 mg. Sec 2 : 512 (Doral)^ AdultsAdultsAdults^ and increase risk of toxicity(Dalmane)^ PO:: : : POPOPO: 1 mg at bedtime. Increase with caution.POPO: : 7.5 to 15 mg at bedtime.: 15 to 30 mg at bedtime.: 15 mg at bedtime. 1 to 2 mg at bedtime. Initial dose: 7.5 mg at bedtime. If not PO: 0.5 mg at bedtime. cigarette smokingmacrolidesdigoxin and 1 10/1/10 9:40:38 AM 0 / 1 / 10 9 : 40 : 38 AM
