(^516) Zolpidem and Zaleplon ● Examples● ActionZolpidem Name Zaleplon (Sonata) CIV/CRamelteon Eszopiclone Generic Chloral hydrate (Trade) Bind to GABA receptors in the CNS. Appear to be selective (Lunesta)(Rozerem)(Ambien)CHEMICAL CLASS: MISCELLANEOUS^ ●^ PSYCHOTROPIC MEDICATIONSCIV/CNot controlled/ Controlled/Pregnancy CIV/CCIV/BCategoriesC 1–2.6 (^1) 2–3 6 (hr)7–10Half-life ●●Indications●●●● InsomniaInsomniaSedationInsomniaInsomniaInsomnia Available Tabs: 8Syrup: 250/5 mL; Tabs: 1, 2, 3Caps: 5, 10Tabs CR: 6.25, 12.5Tabs sublingual: Caps: 500Spray solution, Forms (mg)Tabs: 5, 10actuation500/5 mLlingual: 5 per 5, 10
2506_Ch30_511-521.indd Sec2:516 2506 Ch 30 511 - 521 .indRamelteon ● Contraindicated in:Contraindications and Precautions with other CNS depressants • Pregnancy and lactation ● Eszopiclone ● ● Zolpidem, Zaleplon, Eszopiclone, Ramelteon Chloral Hydrate ● ● Chloral Hydrate ● d Children (sion of the CNS.GABA-receptor complexes near benzodiazepine receptorsHas generally been replaced by safer and more effective agents.for the omegaSevere hepatic, renal, or cardiac impairmentAction as a hypnotic is unclear but thought to interact with Esophagitis, gastritis, or peptic ulcer diseaseRamelteon is a melatonin receptor agonist with high affi for melatonin MTAction unknown. Produces a calming effect through depres-Sec 2 : 516 safety not established^1 -receptor subtype.^1 and MT • Hypersensitivity • In combination^2 receptors. ) nity 1 10/1/10 9:40:40 AM 0 / 1 / 10 9 : 40 : 40 AM
