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● Action● Examples● Generic (Trade) Guanfacine (Tenex; NameClonidine (Catapres)reducing sympathetic outflcreases in peripheral vascular resistance, heart rate, and blood pressure.Mechanism of action in the treatment of ADHD is unknown. Stimulates alpha-adrenergic receptors in the brain, thereby Intuniv)^ AGONISTSCHEMICAL CLASS: ALPHA-ADRENERGIC Agents Used to Treat Attention-DefiHalf-life (hr)Pregnancy Categories/ C/12–16B/16–18 ow from the CNS resulting in de-Indications●●Unlabeled use:●●Unlabeled use:●^ cit/Hyperactivity Disorder ADHDADHD ADHD Hypertension Hypertension (Tenex)(Tenex)(Intuniv)^ Forms (mg)Available Tabs: 0.1, 0.2, 0.3 Transdermal patches: Tabs (ER) Tabs 2, 3, 4 0.1/24 hr, 0.2/24 hr, 0.3/24 hr(Tenex)(Intuniv): 1, 2 ●^ : 1,^529
2 2506_Ch31_522-537.indd 1529 506 Ch 31 522 - 537 .indd Adverse Reactions and Side Effects● ● ● its inactive ingredients ● Use Cautiously in:● 1 ● Contraindications and Precautions ● cardial infarction • Cerebrovascular disease • History of hy-● potension, bradycardia, or syncope • Chronic renal or hepatic Contraindicated in:● failure • Elderly • Pregnancy and lactation● 52 SedationConstipationSyncopePalpitationsBradycardiaFatig ueRebound syndrome with abrupt withdrawalOrthostatic hypotensionDry mouthNausea 9 • Coronary insuffi • Hypersensitivity to the drug or any of ciency • Recent myo- 1 10/1/10 9:40:56 AM 0 / 1 / 10 9 : 40 : 56 AM