Pharmacology for Anaesthesia and Intensive Care

P1: PCX

Printer: Yet To Come

9780521704632c08

CUFX213A/Peck

9780521618168

December 28, 2007

10:38

Table 8.3.Pharmacokinetics of some intravenous anaesthetics.

Dose (mg.kg−^1 )

Volume of

distribution

(l.kg−^1 )

Clearance

(ml.kg−^1 .min−^1 )

Elimination

half-life (h)

Protein

binding (%) Metabolites

Thiopental 3–7 2.5 3.5 6–15 80 active

Methohexitone 1.0–1.5 2.0 11 3–5 60 minimal activity

Propofol 1–2 4.0 30–60 5–12 98 inactive

Ketamine 1–2 3.0 17 2 25 active

Etomidate 0.3 3.0 10–20 1–4 75 inactive

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