Pharmacology for Anaesthesia and Intensive Care

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December 28, 2007

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Table 9.3.Various pharmacological properties of some opioids.

Elimination

half-life (min)

Clearance

(ml.min−^1 .kg−^1 )

Volume of

distribution

(l.kg−^1 )

Plasma protein

bound (%) pKa

Percentage

unionized

(at pH 7.4)

Relative lipid

solubility (from

octanol:water

coefficient)

Morphine 170 16 3.5 35 8.0 23 1

Pethidine 210 12 4.0 60 8.7 5 30

Fentanyl 190 13 4.0 83 8.4 9 600

Alfentanil 100 6 0.6 90 6.5 89 90

Remifentanil 10 40 0.3 70 7.1 68 20

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