Pharmacology for Anaesthesia and Intensive Care

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CUFX213A/Peck

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December 28, 2007

12:27

Table 13.3.Various pharmacological properties of someβ-blockers.

Drug

Lipid

solubility

Absorption

(%)

Bioavailability

(%)

Protein binding

(%)

Elimination

half-life (h) Clearance

Active

metabolites

Acebutolol ++ 90 40 25 6 hepatic metabolism and

renal excretion

yes

Atenolol + 45 45 5 7 renal no

Esmolol +++ n/a n/a 60 0.15 plasma hydrolysis no

Metoprolol +++ 95 50 20 3–7* hepatic metabolism no

Oxprenolol +++ 80 40 80 2 hepatic metabolism no

Pindolol ++ 90 90 50 4 hepatic metabolism no

Propranolol +++ 90 30 90 4 hepatic metabolism yes

Sotalol + 85 85 0 15 renal no

Timolol +++ 90 50 10 4 hepatic metabolism and

renal excretion

no

Labetalol +++ 70 25 50 5 hepatic metabolism no

*Depends on genetic polymorphism – may be fast or slow hydroxylators.

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