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9780521704632c14 CUFX213A/Peck 9780521618168 December 28, 2007 12:32
14 Anti-arrhythmicsDigoxin toxicity
Phenytoin
Although phenytoin is mainly used for its antiepileptic activity, it has a limited role
in the treatment of arrhythmias associated with digoxin toxicity.
Itdepresses normal pacemaker activity while augmenting conduction through
the conducting system especially when this has become depressed by digoxin. It
also demonstrates class I anti-arrhythmic properties by blocking Na+channels.