P1: PSB Printer: Yet To Come
9780521704632ind CUFX213A/Peck 9780521618168 December 29, 2007 17:19
376 Indexremifentanil, 81 , 146–147
clearance, 74
context sensitive half-time, 77 –78
effects, 147
elderly people, 23
kinetics, 147
presentation, 147
target-controlled infusion pumps, 82 –84
uses, 147
renal disease
effects on drug actions, 21
NSAIDs, 151 –152
renal excretion, 20
renal tubules
active transport, 3
diffusion at distal, 20
secretion at proximal, 20
tight junctions, 1
renin–angiotensin–aldosterone system, 258 ,
259f, 262
physiology, 258
repaglinide, 351
reserpine, 264 –265
resting membrane potential, 163
Reye’s syndrome, 153 –154
rifampicin, 41 –42, 324–325
rifamycins, 324 –325
Ringer’s solution, 300
ritodrine, 211
rocuronium, 35 –37, 187
chelation, 24
rofecoxib, 160
ropivacaine, 48 , 171t, 172t
enantiopure preparations, 49
rosiglitazone, 31 , 350–351
route of administration,8–14
epidural, 13 –14
inhalation, 13
intramuscular, 11 –12
intrathecal, 14
intravenous, 8
oral,8–11
rectal, 11
subcutaneous, 12
sublingual, 11
transdermal, 12 –13
ryanodine receptor, 182sacral nerve fibres, 197
salbutamol, 209 –210
effects, 210
inhaled, 13
kinetics, 210
presentation, 209 –210
uses, 209 –210salicylates, 98 , 153–154
see alsoaspirin
salmeterol, 210
Schnider model of TCI, 82
selective serotonin reuptake inhibitors
(SSRIs), 276
semilogarithmic transformation, exponential
wash-out curve,59f
sequestration, intracellular, 72
serotonin (5-HT) receptors, 282
sertraline, 276
sevoflurane, 114 , 122–123
effects, 123
manufacture, 122 –123
metabolism, 123
toxicity, 123
single bolus dose models, 64 –71
single twitch stimulation, 177
sino-atrial node, 228
skin anaesthesia, 12 –13
sodium bicarbonate, 42 , 304t
antacid use, 292
epidural anaesthetics, 14
interaction with calcium, 40
sodium calcium edetate, 41
sodium citrate, 292
sodium ion(s)
conductance during action potential,
164f
loop diuretics reabsorption inhibition, 307
reabsorption inhibition by thiazides, 305
sodium ion channel, 163 –164
cardiac action potential, 228
local anaesthetic binding, 3
quinidine blocking, 236
sodium nitroprusside, 24 , 131t, 246, 248f, 249
effects, 247
kinetics, 247
mechanism of action, 246
metabolism, 247
presentation, 246
toxicity, 248 –249
uses, 246
sodium thiosulphate, 248 –249
sodium valproate, 280 –281
sotalol,226t, 244
spironolactone, 308 –309
Starling equation, 299
stereoisomerism, 45 –49
stereoisomers, optical, 47 –48
steroids, 353 –355
antiemetic use, 291
anti-inflammatory potential,355t
feedback loops affecting production,
354f