Science - USA (2021-10-29)

CREDIT: Y. TAKEI

ET AL.

SCIENCE science.org 29 OCTOBER 2021 • VOL 374 ISSUE 6567 509

RESEARCH

IN BRIEF

574 From Science and other journals

RESEARCH ARTICLES

577 Immunology

p21 produces a bioactive secretome

that places stressed cells under

immunosurveillance I. Sturmlechner et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABB3420;

PERSPECTIVE p. 534

578 Indigenous peoples

Effects of land dispossession and forced

migration on Indigenous peoples in North

America J. Farrell et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABE4943;

PERSPECTIVE p. 536

579 Coronavirus

A pernylated dsRNA sensor protects against

severe COVID-19 A. Wickenhagen et al.

RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:

DOI.ORG/10.1126/SCIENCE.ABJ3624;

PERSPECTIVE p. 535

580 Lipid transport

Distinct allosteric mechanisms of first-

generation MsbA inhibitors F. A. Thélot et al.

586 Nuclear architecture

Single-cell nuclear architecture across cell

types in the mouse brain Y. Ta k e i et al.

REPORTS

594 Phytoplankton

Global drivers of eukaryotic plankton

biogeography in the sunlit ocean

G. Sommeria-Klein et al.

599 Sediment transport

Exceptional increases in fluvial

sediment fluxes in a warmer and

wetter High Mountain Asia D. Li et al.

604 Polymer chemistry

Polyethylene materials with in-chain

ketones from nonalternating catalytic

copolymerization M. Baur et al.

PERSPECTIVE p. 540

608 Superconductivity

Direct evidence for Cooper pairing

without a spectral gap in a disordered

superconductor above T

K. M. Bastiaans et al.

612 Plasmonics

Electrically switchable metallic polymer

nanoantennas J. Karst et al.

616 Magnetism

Intrinsic 2D-XY ferromagnetism

in a van der Waals monolayer

A. Bedoya-Pinto et al.

621 Perovskites

Liquid-phase sintering of lead halide

perovskites and metal-organic framework

glasses J. Hou et al.

Plant Science

625 NIN-like protein transcription factors

regulate leghemoglobin genes

in legume nodules S. Jiang et al.

629 Processing of NODULE INCEPTION

controls the transition to nitrogen

fixation in root nodules

J. Fe n g et al.

SCIENCE (ISSN 0036-8075) is published weekly on Friday, except last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005.Periodicals mail

postage (publication No. 484460) paid at Washington, DC, and additional mailing offices. Copyright © 2021 by the American Association for the Advancement of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic

individual membership, including subscription (12 months): $165 ($74 allocated to subscription). Domestic institutional subscription (51 issues): $2148; Foreign postage extra: Air assist delivery: $98. First class, airmail, student, and

emeritus rates on request. Canadian rates with GST available upon request, GST #125488122. Publications Mail Agreement Number 1069624. Printed in the U.S.A.

Change of address: Allow 4 weeks, giving old and new addresses and 8-digit account number. Postmaster: Send change of address to AAAS, P.O. Box 96178, Washington, DC 20090–6178. Single-copy sales: $15 each plus shipping and

handling available from backissues.science.org; bulk rate on request. Authorization to reproduce material for internal or personal use under circumstances not falling within the fair use provisions of the Copyright Act can be obtained

through the Copyright Clearance Center (CCC), http://www.copyright.com. The identification code for Science is 0036-8075. Science is indexed in the Reader’s Guide to Periodical Literature and in several specialized indexes.

CONTENTS

DEPARTMENTS

511 Editorial

Linking climate and biodiversity

By Ramón Pichs Madruga

650 Working Life

Your peers are your pillars

By Katharina Maisel

AAAS News & Notes ................................. 549

AAAS Annual Meeting .............................. 633

Science Careers ........................................ 640

PERSPECTIVES

534 Clearing stressed cells

Cell cycle arrest produces a

p21-dependent secretome that

initiates immunosurveillance

of premalignant cells By V. Reen and J. Gil

RESEARCH ARTICLE p. 577

535 Defective viral RNA sensing

linked to severe COVID-

Genetic variation in a sensor of

double-stranded RNA can exacerbate

COVID-19 By J. Schoggins

RESEARCH ARTICLE p. 579

536 Documenting indigenous

dispossession

A major data synthesis maps tribal

displacements By D. L. Fixico

RESEARCH ARTICLE p. 578

538 Memories off the top of

your head

Cortical layer 1 has a special

role in long-term memory

By J. N. Shin et al.

540 Polymer design for the

circular economy

Addition of keto groups to

polyethylene helps it degrade

while maintaining its properties

By M. J. Sobkowicz

REPORT p. 604

BOOKS E T A L.

541 The question of canine origins

With few solid leads,

a paleoanthropologist explores

the emergence of the first dogs

By G. Larson

542 Refining the tree of life

Human interventions, both intentional

and unintentional, define a

new chapter in Earth’s storied history

By S. Campbell-Staton

LETTERS

544 WTO must ban harmful

fisheries subsidies

By U. R. Sumaila et al.

544 Alzheimer’s drugs:

Does reducing amyloid work?

By M. Thambisetty et al.

545 Response

By D. J. Selkoe

586