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ACKNOWLEDGMENTS
We thank X. Zhan for advice on the generation ofSprr2a−/−
mice; M. Spence and N. Salinas for assistance with mouse
experiments; P. Doss, R. Roman, R. Jackson, and A. Darehshouri
(UT Southwestern Electron Microscopy Core) for assistance with
electron microscopy; A. Lemoff (UT Southwestern Proteomics
Core) for assistance with mass spectrometry; B. Evers (UT
Southwestern Histopathology Core) for assistance with mouse
histology analysis; and E. Burstein for collaboration on patient
sample collection.Funding:This work was supported by NIH
grants R01 DK070855 (L.V.H.), R01 AI130020 (T.A.R.), and K99
DK120897 (Z.K.); Welch Foundation Grant I-1874 (L.V.H.); American
Heart Association Grant 17SDG33670071 (T.A.R.); Cancer
Prevention and Research Institute of Texas Grant RP200118
(T.A.R.); the Pew Charitable Trusts (T.A.R.); the Walter M. and
Helen D. Bader Center for Research on Arthritis and Autoimmune
Diseases (L.V.H.); and the Howard Hughes Medical Institute
(L.V.H.). C.M.Z., Z.K., and M.P. were supported by NIH T32 AI005284.
Author contributions:Z.H., C.Z., T.A.H.-T., T.A.R., and L.V.H.
designed research. Z.H., C.Z., L.S.-D., C.M.Z., D.C.P., Z.K., Y.W.,
M.P., K.A.R., B.H., C.L.B., B.Z., and P.R. performed research. Z.H.,
C.Z., L.S.-D., and P.R. analyzed data. Z.H., C.Z., T.A.R., and
L.V.H. wrote the paper.Competing interests:The authors declare
no competing interests.Data and materials availability: 16 S
rRNA gene sequencing data are available from the Sequence Read
Archive (SRA) under project ID PRJNA743545. All other data are
available in the main text or the supplementary materials.SUPPLEMENTARY MATERIALS
science.org/doi/10.1126/science.abe6723
Figs. S1 to S17
Tables S1 to S3
Reference ( 47 )
MDAR Reproducibility Checklist6 September 2020; resubmitted 2 April 2021
Accepted 9 September 2021
10.1126/science.abe6723Huet al.,Science 374 , eabe6723 (2021) 5 November 2021 13 of 13
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