SCIENCEscience.org 5 NOVEMBER 2021¥VOL 374 ISSUE 6568 737
Fig. 3. Substrate scope.Reaction conditions for alkenyl triflate: alkenyl triflate
(0.10 mmol),R4orR8(0.22 mmol), Pd(COD)Cl 2 (0.01 mmol),L1(0.012 mmol),
N10(0.10 mmol), 5-CF 3 -2-pyridoine (0.02 mmol), Cs 2 CO 3 (0.20 mmol),
toluene (1.5 ml), 1,4-dioxane (0.5 ml), and 100°C for 24 hours. Isolated average
yields of two runs are reported. *R8was used.†Cs 2 CO 3 and Tf 2 O were used.
‡2.0 mmol scale with 5 mol % Pd(COD)Cl 2 and 50 mol %N10. §1.0 mmol
scale. ¶LiTMP and NfF were used. #R4was used. **3,5-di-CF 3 -2-pyridone
was used.††15 mol % Pd(COD)Cl 2 was used. See supplementary materials
for details. Et, ethyl; Nf, nonaflyl; OAc, acetate; rr, regioisomeric ratio; THF,
tetrahydrofuran; Ts, tosyl.RESEARCH | REPORTS