Dolly the sheep was successfully cloned in 1996 by fusing the nucleus from a
mammary-gland cell of a Finn Dorset ewe into an enucleated egg cell taken
from a Scottish Blackface ewe. Carried to term in the womb of another
Scottish Blackface ewe, Dolly was a genetic copy of the Finn Dorset ewe.
Encyclopædia Britannica, Inc.
7 Ian Wilmut 7be accomplished through fusion of the cell to the egg
(the technique that Wilmut used in all his later cloning
experiments) or through the removal of the nucleus from
the cell and the subsequent transplantation of that nucleus
into the enucleated egg cell (a technique refi ned in the
early 2000s). In 1989 Wilmut and Lawrence Smith, a
graduate student conducting his thesis research at Roslin,
generated four cloned lambs by using embryonic cell
nuclear transfer, in which the nucleus from an embryonic
stem cell was inserted into an enucleated egg. This research
led Wilmut and Smith to an important discovery—namely,
that the stage of the cell cycle (the sequence through which