Mood Disorders and Suicide 215
FEEDBACK LOOPS IN TREATMENT: Depressive Disorders
The goals of any treatment for depressive disorders are ultimately the same:
- to reduce symptoms of distress and depressed mood and negative or unrealistic
thoughts about the self (psychological factors),
- to reduce problems related to social interactions—such as social withdrawal—and
to make social interactions more satisfying and less stressful (social factors), and
- to correct imbalances in the brain associated with some of the symptoms, such as by
normalizing neurotransmitter functioning or hormone levels (neurological factors).
Treatments that target one type of factor also affect other factors. CBT, for
instance, not only can lessen psychological symptoms, but can also change brain
activity (Goldapple et al., 2004), improve physical symptoms (including disrupted
sleep, appetite, and psychomotor symptoms), and improve social relations. More-
over, as we saw in Chapter 5, medication for depression works not just through its
effects on neurological functioning, but also through the placebo effect. Thus, a de-
pressed patient’s beliefs (psychological factor) can account for much of the effect of
antidepressant medication. Figure 6.3 illustrates the various treatments discussed;
the targets of treatments for depressive disorders, and the feedback loops that arise
with successful treatment.
Note that Figure 6.3 lists the various types of treatment for depressive disorders,
sorted into the three types of factors; in two cases—medication and CBT—we go one
step further and list specifi c types of drugs and specifi c CBT methods. Why are we
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Figure 6.3
6.3 • Feedback Loops in Treating Depressive Disorders
Treatments Targeting
Neurological Factors
Treatments Targeting
Targeting Psychological Factors
Treatments Targeting
Social Factors
Changes neural
activity
Changes thoughts,
feelings, and
behaviors
Changes social
interaction
Decreases family
conflict
Medication: SSRIs,
SNRIs, TCAs, MAOIs
ECT
TMS
IPT
Family systems
therapy
CBT: Behavioral
activation, cognitive
restructuring