The following are the endocrine disorders which are common in
uraemic patients:- Hyperparathyroidism • Lack in activation of vit. D.
- Increased renin activity • Lack of erythropoietin
- Decreased testosterone level resulting in a decreased libido, potency
and spermatogenesis. - Increased prolactin and L.H. causing menstrual disorders, gynecomastia
and infertility. - Insulin: there are two opposing effects of uraemia on insulin. The first
effect is tissue resistance to insulin due to the uraemic milieu. The
second is decreased renal tubular degradation of insulin with a
consequent increase in the insulin half life. The upper hand is usually
for the second effect with consequent fall in insulin requirement
(insulin daily dose) in diabetic patients when they become uraemic.
X. Features of the underlying disease may be present:
As manifestations of D.M., SLE or renal stone disease.