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b. Complications due to individual drugs:



  1. Steroids: hypertension, D.M., atherosclerosis, Bone disease, GIT
    bleeding and cataract.

  2. Azathioprine: Bone marrow depression and hepatic dysfunction
    3- Cyclosporine: Nephrotoxicity, hepatotoxicity, hypertension and D.M.


3- Recurrence of the original kidney disease into the graft (e.g. FSGS,
MPGN)


Outcome after transplantation:


  • The outcome of kidney transplantation is continuously improving with
    the advances in the immunosuppressive drugs and the immunologic
    assessment of donors and recipients, technique of surgery and the
    postoperative care.

  • The current 1 year graft survival is about 90-95% and 5 years graft
    survival is about 60-70%.

  • Continuous advancement in immunosuppressive drugs aims to an ideal
    drug with maximal ability to prevent rejection and minimal side effects.

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