b. Complications due to individual drugs:
- Steroids: hypertension, D.M., atherosclerosis, Bone disease, GIT
bleeding and cataract. - Azathioprine: Bone marrow depression and hepatic dysfunction
3- Cyclosporine: Nephrotoxicity, hepatotoxicity, hypertension and D.M.
3- Recurrence of the original kidney disease into the graft (e.g. FSGS,
MPGN)
Outcome after transplantation:- The outcome of kidney transplantation is continuously improving with
the advances in the immunosuppressive drugs and the immunologic
assessment of donors and recipients, technique of surgery and the
postoperative care. - The current 1 year graft survival is about 90-95% and 5 years graft
survival is about 60-70%. - Continuous advancement in immunosuppressive drugs aims to an ideal
drug with maximal ability to prevent rejection and minimal side effects.