5- Drugs and toxins producing combined Hepatic and Renal damage.
A- Drugs causing hepatic injury and acute tubular necrosis:
- Hallogenated hydrocarbons as carbon tetrachloride, chloroform
and chlorethylene - Hallogenated anaesthetics as Halothane and Methoxyflurane
- Tetracycline • Sulfonamides
- Rifampicin • Acetaminophen
- Methotrexate • Arsenic
- Copper sulphate
B- Hepatic injury and acute interstitial nephritis - Sulfonamides • Phenindione
- Rifampicin • Allopurinol
Hepatorenal Syndrome (HRS)
Definitions :-
HRS is an unexplained, functional renal failure occurring in
patients with advanced liver disease. The diagnosis of HRS is considered
when there is no laboratory or anatomic evidence of other known cause of
renal failure.
HRS occurs in patients with cirrhosis, acute hepatitis, fulminant
hepatic failure and with hepatic malignancy.