Microsoft Word - final.doc

Glomerular damage

Proteinuria

Hypoalbuminaemia

Decreased plasma oncotic

pressure

Starling Forces

Water retention OEDEMA

Decreased effective

circulating blood volume

Water retention

Increased

ADH

Increased Renin-

angiotensin,Aldosterone.

decreased ANP

(Fig. 3.7)

Mechanisms of oedema formation in patients with nephrotic

syndrome

2. Loss of intravascular fluids results in hypovolaemia (reduction of
   circulating blood volume) which a. stimulates the kidney
   (juxtaglomerular apparatus) to secrete Renin, b. stimulates volume
   receptors which stimulate the hypothalamus that stimulates pituitary
   secretion of antidiuretic hormone (ADH), and c. stimulates volume