496 INDEX
electron transfer kinetics and, 144
hammerhead crystal structures and,
267t, 269–272, 270–271t, 279,
282, 287–288, 291, 294, 297
homeostasis and, 197, 199
isoelectric for amino acids, 40 –41
oxygen carriers
passive diffusion and, 195
physiological, 31f, 32, 32f
protein crystallization and, 84
proton channels and, 194
Phage display, 69
Phenylalanine (Phe, F), 31f
calmodulin and, 304, 314–316, 315t,
324
cytochrome c and, 415, 424
hemoglobin and myoglobin and, 346,
350 –351
Na+/K+ ATPase and, 201
potassium ion channels, 209
zinc fi ngers and, 64
Phosphates, 4t, 7, 7t
nucleotides and, 24, 47–50, 48t, 50f,
55, 65, 69, 201–202, 212
group I intron and, 244–261, 254f
hammerhead ribozyme and, 261–301
homeostasis and, 192–194
prochiral, 243, 244f
ribozymes and, 240–244
scissile phosphate, 250, 255, 257–261,
264f, 265f, 266f, 268–269, 279–
281, 284, 286, 293f, 296, 300
Phosphodiester groups, 47, 55, 68, 239,
242, 244, 263, 265, 269, 280, 284,
289, 292–293
Phosphorus (P), 1–2, 7t, 107, 192–194,
243
group I intron and, 257–262, 360f
hammerhead ribozyme and, 269, 272,
279, 287, 296
prochiral, 243, 244f
P type-ATPases and, 335
Phosphorylation, 56, 193, 200, 244, 260,
319, 321, 323, 327, 329, 333–337,
388, 430
Phosphatases, 191t, 302, 327, 459
Plasmids, 59– 61, 60f
Platinum (Pt), 14, 16, 19, 96
spin-spin coupling and, 106 –107, 106f
Platinum-containing anticancer agents:
cis-dichlorodiammineplatinum(II),
cisDDP, cisplatin, 16, 16f, 20, 20f,
47, 53, 55, 141
drug resistance, 55
Po1ak-Ribiere minimizer, 165
Polyacrylamide gel electrophoresis.
Two-dimensional (2-DE or 2-D
gels), 41–42, 269, 272
Polyethyleneglycol (PEG), 84
Polymerase chain reaction (PCR), 60 –
61, 141
Polymerization, 30
Polypeptide chains, formation of, 30,
33–35, 34f
Porphyrin: see also heme(s)
capped, 354, 356
π-cation radical, 364–366, 370, 372,
375–376, 379, 382
picket-fence, 90 –91, 135t, 350 –352,
351t, 352t, 354–356, 355f, 356f,
441
Potassium (K), 1, 2t, 4t, 6, 7t, 9, 9t, see
also alkali metals, Na+/K+-
ATPase, potassium ion channels
Potassium (K+) ion channels, 199,
203–235
basic information, 203–205
biotinylation and, 220–221, 220f, 224,
233–234
inactivation peptides and, 204, 212–
214, 229–231
ion conduction (pore), 209, 212,-215,
217f, 222–227, 230 –234
KvAP and, 204, 206–207t, 209f, 214–
215, 218, 223–234
monoclonal antibodies (Fabs) and,
204, 206–207t, 215, 225, 229
pore(s) and, 194, 204–205, 206–207t,
208–209, 208f, 210f, 211–216,
217f, 218–235
Shaker channels and, 204–205, 208–
209, 208f, 223–232
tetraethylammonium (TEA) ion and,
209, 212
voltage-dependent (voltage-gated),
197, 199, 204–205, 206–207t,
208–209, 212–218, 213f, 219f,
224–225, 229