Advices For Studying Organic Chemistry

1) The synthesis of vitamin B 12 took 11 years, required 90 steps, and involved the

work of nearly 100 people.

4. Two types of transformations involved in organic synthesis:
   
   
   1. Converting functional groups from one to another.
   
   
   2. Creating new C—C bonds.
   
   
   
   


5. The heart of organic synthesis is the orchestration of functional group
   interconversions and C—C bond forming steps.

4.20A RETROSYNTHETIC ANALYSIS –––

PLANNING AN ORGANIC SYNTHESES

1. Retrosynthetic Analysis:
   
   
   1. Often, the sequence of transformations that would lead to the desired compound
      (target) is too complex for us to “see” a path from the beginning to the end.
      i) We envision the sequence of steps that is required in a backward fashion, one
      step at a time.
   
   
   2. Begin by identifying immediate precursors that could be transformed to the
      target molecule.
   
   
   3. Then, identifying the next set of precursors that could be used to make the
      intermediate target molecules.