242 GUTH
invited me to his office, spoke to me at length, and, assuring me
that I was not imposing on his time, invited me to return when
ever I wished. I took advantage of his kindness and spent many
hours listening to him and learning from him. Little did I realize
how much more I was to gain from this friendship. Two years
later, I completed an experiment in which I had reinnervated the
muscle of the diaphragm with the vagus nerve. I discussed the re
sults with Frank who pointed out that the interpretation would
be clarified greatly by making electrophysiological recordings of
the nervous activity in the vagus nerve and its recurrent laryngeal
branch. He invited me into his laboratory to observe while he
performed the recordings on animals that I had prepared for him.
When the resultant manuscript was ready for publication, I showed
it to Windle who told me that he would like to publish it in a new
journal that he had just founded. I am proud to this day that this
paper, by Lloyd Guth and Karl Frank, appeared as Volume 1,
Number 1, Page 1, of Experimental Neurology.^14
•I want to offer one last anecdote, because it illustrates that
generous helpfulness can have remarkably long-lasting effects.
One day in about 1958, Frank introduced me to a visitor, Paul O.
Chatfield, and mentioned that Chatfield was author of a recently
published treatise on neurophysiology.^15 I purchased the book
and of all its chapters I found myself most intrigued by one dealing
with the crossed phrenic phenomenon. My curiosity was piqued
because, despite numerous experimental investigations, the basis
for this unusual phenomenon had remained elusive for more than
60 years. Furthermore, try as I might, I could not formulate an
experimentally-testable hypothesis to explain it. Consequently,
for the next 15 years, I put the subject out of mind while I worked
on unrelated subjects. But the enigma of the crossed phrenic phe
nomenon must have remained within my subconscious because,
in 1974, a testable hypothesis abruptly came to me. The idea did
not occur as a sudden burst of inspiration nor as a result of care
ful re-examination of the subject. It just seemed to emerge despite
my not having given serious thought to the subject for many years.
At that time, Harry Goshgarian had just joined the laboratory