SCIENCEscience.org 10 DECEMBER 2021¥VOL 374 ISSUE 6573 1349
B CDEF GATCID50/SwabFig. 6. Efficacy of mRNA-1273 against upper and lower respiratory B.1.351
viral replication.(A) Abbreviated schema: Rhesus macaques were immunized
and challenged. (BtoE) BAL [(B) and (D)] and NS [(C) and (E)] samples were
collected on day 2 (circles), day 4 (squares), and day 7 (triangles) after
challenge, where applicable. Viral replication was assessed by detection of
SARS-CoV-2_E sgRNA [(B) and (C)], and viral titers were assessed by TCID 50
assay [(D) and (E)]. For (B) to (E), boxes and horizontal bars denote the IQRs
and medians, respectively; whisker end points are equal to the maximum and
minimum values. For (F) and (G), plots show correlations between viral titers
and sgRNA_E in BAL (F) and NS (G) 2 days after challenge. Black and gray lines
indicate linear regression and 95% confidence interval, respectively.rand
Prepresent SpearmanÕs correlation coefficients and correspondingPvalues,
respectively. Symbols represent individual NHPs and may overlap for equal
values. Dotted lines indicate assay limits of detection.RESEARCH | RESEARCH ARTICLES