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ACKNOWLEDGMENTS
We acknowledge M. Gai and the Open Lab of Advance Microscopy
(OLMA@MBC) for technical assistance.Funding:This work was
supported by Associazione Italiana Ricerca Cancro (AIRC; 21875 to
E.H.), Leducq Foundation (19CVD02 to E.H.), PRIN (20177E9EPY
to E.H.), Fondazione Ricerca Molinette (to E.H.), Fondazione
Pezcoller-SIC“Patrizia Coser”(to F.G.), Fondazione Italiana per la
Ricerca sul Cancro (FIRC 22558 to J.P.M. and FIRC 22248 to
M.C.D.S.), Deutsche Forschungsgemeinschaft (DFG) (TRR186/
A08 to V.H. and SCHU 3314/1-1 to M.S.), NeuroCure Cluster of
Excellence (Charité Universitätsmedizin Berlin, 10117 Berlin,
Germany to V.H.), National Institute of Diabetes and Digestive
and Kidney Diseases (DK119305 to D.A.B.), and Sigma Xi research
foundation (to A.C.).Author contributions:F.G. designed and
performed research, analyzed data, and wrote the manuscript;
L.P., H.L., I.C., S.J.C., A.M., P.K., A.C., J.F., A.Y., W.-T.L., N.T.S.,
M.C.D.S, and J.P.M. performed research and analyzed data; O.V.,
D.R.P., H.N.B., D.T., R.L.W., M.T., T.B., B.M.D., M.S., M.S.W.,
A.G., M.M., B.D.P., V.H, E.B, G.R.M., and D.A.B. provided critical
reagents and supervised the work; E.H. designed the research,
supervised the work and wrote the manuscript.Competing
interests:E.H. and A.G. are cofounder and board member
of Kither Biotech, a pharmaceutical product company developing
PI3K inhibitors for the treatment of respiratory diseases not in
conflict with statements made in this article. The other authors
declare no conflict of interest.Data and materials availability:All
data are available in the manuscript or the supplementary materials.
PITCOIN1 is subject to a European patent application (application
no. PCT/EP2019/065009), and its distribution is dependent on
completion of a materials transfer agreement with the FMP.
SUPPLEMENTARY MATERIALS
science.org/doi/10.1126/science.abk0410
Figs. S1 to S20
Tables S1 to S3
MDAR Reproducibility Checklist
Movies S1 to S717 June 2021; accepted 26 October 2021
10.1126/science.abk0410Gulluniet al.,Science 374 , eabk0410 (2021) 10 December 2021 14 of 14
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