Matthews, D.E., Marano, M.A. & Campbell, R.G. (1993)
Splanchnic bed utilization of glutamine and glu-
tamic acid in humans. American Journal of Physiology
264 , E848–E854.
Nurjhan, N., Bucci, A., Perriello, G., Stumvoll, N.,
Dailey, G., Bier, D.M., Toft, I., Jenssen, T.G. & Gerich,
J.E. (1995) Glutamine: a major gluconeogenic precur-
sor and vehicle for interorgan carbon transport in
man.Journal of Clinical Investigation 95 , 272–277.
Owen, O.E., Felig, P., Morgan, A.P., Wahren, J. & Cahill,
G.F. (1969) Liver and kidney metabolism during pro-
longed starvation. Journal of Clinical Investigation 48 ,
574–583.
Pacy, P.J., Price, G.M., Halliday, D., Quevedo, M.R. &
Millward, D.J. (1994) Nitrogen homeostasis in man:
the diurnal responses of protein synthesis and de-
gradation and amino acid oxidation to diets with
increasing protein intakes. Clinical Science 86 ,
103–118.
Perriello, G., Jorde, R., Nurjhan, N.et al.(1995) Estima-
tion of glucose–alanine–lactate–glutamine cycles in
postabsorptive humans: role of skeletal muscle.
American Journal of Physiology 269 , E443–E450.
Rennie, M.J. (1996) Influence of exercise on protein and
amino acid metabolism. In Handbook of Physiology.
Section 12, Exercise: Regulation and Integration of Mul-
tiple Systems(ed. L.B. Rowell & J.T. Shepherd), pp.
995–1035. Oxford University Press, Oxford.
Rennie, M.J., Edwards, R.H.T., Halliday, D., Matthews,
D.E., Wolman, S.L. & Millward, D.J. (1982) Muscle
protein synthesis measured by stable isotope tech-
niques in man: the effects of feeding and fasting.
Clinical Science 63 , 519–523.
Rennie, M.J., Babij, P., Taylor, P.M.et al.(1986) Charac-
teristics of a glutamine carrier in skeletal muscle
have important consequences for nitrogen loss in
injury, infection and chronic disease. Lancet 2 ,
1008–1012.
Ross, B.D., Hems, R. & Krebs, H.A. (1967) The rates of
gluconeogenesis from various precursors in the per-
fused rat liver. Biochemical Journal 102 , 942–951.
Ruderman, N.B. & Lund, P. (1972) Amino acid metabo-
lism in skeletal muscle: regulation of glutamine and
alanine release in the perfused rat hindquarter. Israel
Journal Medical Sciences 8 , 295–302.
Sahlin, K., Katz, A. & Broberg, S. (1990) Tricarboxylic
acid cycle intermediates in human muscle during
prolonged exercise. American Journal of Physiology
259 , C834–C841.
Spencer, M.K., Yan, Z. & Katz, A. (1992) Effect of glyco-
gen on carbohydrate and energy metabolism in
human muscle during exercise. American Journal of
Physiology 262 , C975–C979.
Souba, W.W. (1991) Glutamine: a key substrate for the
splanchnic bed. Annual Reviews of Nutrition 11 ,
285–308.
Van Acker, B.A.C., Hulsewé, K.W.E., Wagenmakers,
A.J.M.et al. (1998) Absence of glutamine isotopic
steady state: implications for studies on glutamine
metabolism.Clinical Science 95 , 339–346.
Van Hall, G. (1996) Amino acids, ammonia and exercise in
man. Thesis, Maastricht University, The Netherlands.
Van Hall, G., Raaymakers, J.S.H., Saris, W.H.M. &
Wagenmakers, A.J.M. (1995a) Ingestion of branched-
chain amino acids and tryptophan during sustained
exercise: failure to affect performance. Journal of
Physiology 486 , 789–794.
Van Hall, G., Saltin, B., van der Vusse, G.J., Söderlund,
K. & Wagenmakers, A.J.M. (1995b) Deamination of
amino acids as a source for ammonia production in
human skeletal muscle during prolonged exercise.
Journal of Physiology 489 , 251–261.
Van Hall, G., MacLean, D.A., Saltin, B. &
Wagenmakers, A.J.M. (1996) Mechanisms of activa-
tion of muscle branched-chain a-keto acid dehydro-
genase during exercise in man. Journal of Physiology
494 , 899–905.
Vinnars, E., Bergström, J. & Fürst, P. (1975) Influence
of the postoperative state on the intracellular free
amino acids in human muscle tissue. Annals of
Surgery 182 , 665–671.
Wagenmakers, A.J.M. (1992) Role of amino acids
and ammonia in mechanisms of fatigue. In Muscle
Fatigue Mechanisms in Exercise and Training,Medicine
and Sport Science, Vol. 34 (ed. P. Marconnet, P.V. Komi,
B. Saltin & O.M. Sejersted), pp. 69–86. Karger, Basel,
Switzerland.
Wagenmakers, A.J.M. & Soeters, P.B. (1995) Metabo-
lism of branched-chain amino acids. In Amino Acid
Metabolism and Therapy in Health and Nutritional
Disease(ed. L.A. Cynober), pp. 67–83. CRC Press,
New York.
Wagenmakers, A.J.M. & Van Hall, G. (1996) Branched-
chain amino acids: nutrition and metabolism in exer-
cise. In Biochemistry of Exercise IX(ed. R.J. Maughan
& S.M. Shirreffs), pp. 431–443. Human Kinetics,
Champaign, IL.
Wagenmakers, A.J.M., Salden, H.J.M. & Veerkamp, J.H.
(1985) The metabolic fate of branched-chain amino
acids and 2-oxo acids in rat muscle homogenates and
diaphragms.International Journal of Biochemistry 17 ,
957–965.
Wagenmakers, A.J.M., Coakley, J.H. & Edwards, R.H.T.
(1990) Metabolism of branched-chain amino acids
and ammonia during exercise: clues from McArdle’s
disease.International Journal of Sports Medicine 11 ,
S101–S113.
Wagenmakers, A.J.M., Beckers, E.J., Brouns, F., Kuipers,
H., Soeters, P.B., van der Vusse, G.J. & Saris, W.H.M.
(1991) Carbohydrate supplementation, glycogen
depletion, and amino acid metabolism during exer-
cise.American Journal of Physiology 260 , E883–E890.