N2 - 2N - -2R - - 2D-Al -A2 - A,,
Dimer monomer Ionization-linked Reversible Type I aggregation Type I1 aggregation
dissociation transition denaturation
Irreversible denaturationlaggregation
Figure 9.16 Stages in the thermal denaturation of /I-lactoglobulin (from Mulvihill and Donovan, 1987).