Textbook of Personalized Medicine - Second Edition [2015]

205 These results suggest that gene expression profi ling of breast biopsies may become a valuable method for adequately charact ...

206 Circulating Cancer Cell Analysis for Personalizing Therapy Blood samples can now analyzed for circulating tumor cells (CTCs) ...

207 Detection capability: 0.01 % (mutant/total DNA) 1–4 (i.e. ≥1 mutant DNA molecule in 10,000 wild type DNA molecules) Turnaro ...

208 the level of cytogenetic visibility, a decrease that is still ongoing in many patients 15 months after attainment of a compl ...

209 elevated cell proliferation. Expression profi ling of these genes can provide useful information about cancer and planning i ...

210 identify new therapeutic strategies that make use of all available drugs. The devel- opment of gene expression profi les tha ...

211 Isolation and Characterization of Circulating Cancer Cells Viable tumor-derived epithelial cells (circulating cancer cells o ...

212 NanoFlares for Detection of CTCs NanoFlares are nanoconstructs that enable live-cell detection of intracellular mRNA. NanoFl ...

213 outcomes. Combining signature-based predictions across several pathways identifi es coordinated patterns of pathway deregula ...

214 Role of Molecular Imaging in Personalized Therapy of Cancer In oncology, if cancer cells are removed from their microenviron ...

215 brain tumors showed changes in the diffusion map if chemotherapy or radiation therapy was having any effect. It worked withi ...

216 imaging method for personalized cancer treatment by identifying and monitoring patients who have increased tumor tryptophan ...

217 techniques is creating the scaffolding for the evolving paradigm shift to personalized cancer therapy (Kurdziel et al. 2008 ...

218 tumor, have the worst prognosis. Molecular tests for TP53 and RER are already considered to offer prognostic value in certai ...

219 Effective targeted cancer therapeutic development depends upon distinguishing disease-associated ‘driver’ mutations, which h ...

220 Impact of Biomarkers on Management of Cancer Biomarkers are playing an important role in the diagnosis as well as management ...

221 for enhancing L-ASP activity by combining it with antagonists of ASNS, such as siRNAs, antisense nucleotides, antibodies or ...

222 Sequencing to Discover Biomarkers to Personalize Cancer Treatment A sequencing-based method for personalized analysis of rea ...

223 VeraTag™ Assay System for Cancer Biomarkers The VeraTag™ assay system (Monogram Biosciences) is a high performance, high thr ...

224 ERCC1- XPF as a biomarker in clinical specimens that could help stratify patients according to cancer risk, response to trea ...