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Applications of Pharmacoproteomics
in Personalized Medicine
Examples of clinical applications of proteomic technologies will be given in various
chapters dealing with therapeutic areas. Advantages of use of pharmacoproteomics
in personalized medicine are:
- Pharmacoproteomics is a more functional representation of patient-to-patient
variation than that provided by genotyping. - Because it includes the effects of post-translational modifi cation, pharmacopro-
teomics connects the genotype with the phenotype. - By classifying patients as responders and non-responders, this approach may
accelerate personalized drug development. - Protein biomarkers facilitate integration of diagnostics with therapeutics from
development stages to translation into clinical applications. - Global development of personalized medicine would benefi t from pharmacopro-
teomics technologies and the ways in which they are being applied in Asia-
Pacifi c, particularly India, where there is extensive research investments in
“-omics” technologies (Reddy et al. 2011 ).
References
Hess S. The emerging fi eld of chemo- and pharmacoproteomics. Proteomics Clin Appl. 2013;7:
171–80.
Jain KK. Role of pharmacoproteomics in the development of personalized medicine.
Pharmacogenomics. 2004;5:331–6.
Jain KK. Proteomics: technologies, markets and companies. Basel: Jain PharmaBiotech; 2015.
Reddy PJ, Jain R, Paik YK, et al. Personalized medicine in the age of pharmacoproteomics: a close
up on India and need for social science engagement for responsible innovation in post-
proteomic biology. Curr Pharm Pers Med. 2011;9:67–75.
VanMeter A, Signore M, Pierobon M, et al. Reverse-phase protein microarrays: application to
biomarker discovery and translational medicine. Expert Rev Mol Diagn. 2007;7:625–33.
6 Pharmacoproteomics