xxxvList of Tables
Table 1.1 Selected terms relevant to the concept of personalized
medicine ........................................................................................ 2
Table 1.2 Landmarks in the historical development
of personalized medicine ............................................................... 4
Table 1.3 Genetic variations in the human genome ...................................... 10
Table 2.1 Molecular diagnostic technologies used
for personalized medicine.............................................................. 36
Table 2.2 Applications of biochip technology relevant
to personalized medicine ............................................................... 46
Table 2.3 Technologies for SNP analysis ...................................................... 63
Table 2.4 Comparison of proteomic and genomic approaches
in personalized medicine ............................................................... 76
Table 2.5 Selected methods for gene expression profi ling ............................ 77
Table 2.6 Drugs requiring biomarker/companion diagnostic
information in the label ................................................................. 83
Table 2.7 Applications of point-of-care diagnosis ........................................ 85
Table 4.1 Enzymes relevant to drug metabolism .......................................... 103
Table 4.2 Examples of mutation of the enzyme CYP450 ............................. 104
Table 4.3 Frequency distribution of drugs metabolized
by major isoforms of CYP450 ....................................................... 104
Table 4.4 Commonly prescribed medications, which are metabolized
by CYP2D6 ................................................................................... 104
Table 4.5 Polymorphisms in drug target genes that can infl uence
drug response ................................................................................. 112
Table 4.6 Effect of genetic polymorphisms on disease
response to drugs ........................................................................... 113
Table 4.7 Examples of genetically determined adverse
reactions to drugs ........................................................................... 118
Table 4.8 Examples of genotyping and phenotyping in some diseases ........ 129
Table 4.9 Pharmacogenomic biomarkers in drug labeling ............................ 135