K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7, 709
© Springer Science+Business Media New York 2015
A
Acquired immunodefi ciency syndrome (AIDS)
biomarkers , 397–398
CD4 counts , 397
chemotherapeutic agents , 393
copy number variations , 12
drug-resistance , 398–399
gene therapy strategies , 400–401
HAART , 394
HIV genotyping, cost-effectiveness of , 689
pathogenesis , 391–392
A C T. See Adoptive cell therapy (ACT)
Acupuncture , 3, 577–578
Acute lymphoblastic leukemia (ALL) , 264–265
L-ASP therapy , 220
personalized management of , 327–328
TPMT genetic test , 267
19z1 CAR , 249
Acute myeloid leukemia (AML)
BH3 profi ling , 330
cytarabine , 329
FLT3 mutations , 328–329
ITD mutations , 329
risk stratifi cation , 329
WT1 RQ-PCR test , 328, 329
Adcetris™ , 336
ADHD. See Attention defi cit hyperactivity
disorder (ADHD)
Adoptive cell therapy (ACT)
antiangiogenic agents , 248–249
B cell malignancies, human T cells , 249
EBV-specifi c CTL , 248
features , 247
hybrid cell vaccination approach , 250
tumor cells, genetic engineering of , 250
Adverse drug reactions (ADR)
DMARD , 555
EHRs , 640–641
pharmacogenetics , 688–689
AED treatment , 431
chemotherapy , 116
clinical trials , 132–133
elders , 569
fatal ADR , 115
genetically determined ADR , 117–118
genetic susceptibility , 143
in infants and young children , 115, 116
postmarketing surveillance , 143–144
warfarin therapy , 120
TDM , 126, 471
Aerobic exercise , 584–585
Affordable Care Act , 656
Agency for Healthcare Research and Quality
(AHRQ) , 605–607
AIDS. See Acquired immunodefi ciency
syndrome (AIDS)
ALL. See Acute lymphoblastic leukemia
(ALL)
Allele-specifi c inhibition (ASI) , 195
Allogeneic hematopoietic stem cell
transplantation (allo-HSCT) ,
249, 265
AlloMap MolecularTesting , 559–560
Alpha-(11)C-methyl-l-tryptophan (AMT) ,
215–216
Alpha-fetoprotein (AFP) , 290, 535
Alzheimer’s disease (AD)
ApoE gene , 153, 420
defi nition , 418
diagnosis of , 418–419
future management , 421
GAB2 gene , 420
genetic databases , 24
genomic research in , 420Index