710
Alzheimer’s disease (AD) (cont.)
hypertension , 493
LOAD susceptibility gene , 420
molecular imaging , 601–602
protein misfoldings , 161
racial and ethnic groups , 662
American Medical Association (AMA) , 629
American Recovery and Reinvestment Act
(ARRA) , 605, 607
AML. See Acute myeloid leukemia (AML)
Anaplastic lymphoma kinase (ALK) , 273, 347
Anaplastic oligoastrocytoma (AOA) , 288
Anaplastic oligodendroglioma (AO) , 288
Androgenetic alopecia , 570
Angiotensin converting enzyme (ACE)
inhibitors , 488, 573
Anti-citrullinated protein antibodies
(ACPAs) , 558
Anticoagulant therapy , 503–504
Antidepressant therapy, psychiatric disorders
biomarker , 468
EEG , 468–469
enzymes , 468
protein sFRP3, role of , 471–472
smoking cessation , 476
SSRI treatment , 469–471
treatment resistant depression , 472
vilazodone , 472
Antiplatelet therapy
pharmacogenetics, role of , 121–122
thrombotic disorders , 504–505
Antisense therapy , 194–195
microRNAs (miRNAs) , 196
RNA interference , 195–196
Apolipoprotein B mRNA-editing enzyme,
catalytic polypeptide-like 3G
(APOBEC3G) , 397
ARIUS approach , 238
Arrayed primer extension (APEX) , 39
Arrayit ® H25K , 49
Asparagine synthetase (ASNS) , 220–221
Asthma
corticosteroid therapy , 516
cytokines , 516–517
endothelin-1 , 518
exhaled NO , 517–518
genotyping
β 2 -adrenergic agonists , 520
eNOS downregulation , 519
iNOS upregulation , 519
risk stratifi cation , 519
SNP , 520
IgE , 518–519
lebrikizumab , 520–521
rhinovirus infection , 516
Astrocyte elevated gene-1 (AEG-1) , 345
Astronauts , 574
Atherosclerosis , 487, 570–571
Atomic force microscopy (AFM) , 187
Attention defi cit hyperactivity disorder
(ADHD) , 181, 472–473
Avastin , 687
AVESTAGENOME Project™ , 696
AVIGA REPORTER™ , 638
Ayurveda , 3, 4B
Bacterial infections
genomics and sequencing
antibiotic resistance , 384
microbial fl ora, leg ulcers , 383–384
MRSA, virulence of , 384–385
molecular diagnosis, POC , 385
sepsis , 386
tuberculosis , 386–387
vaccines , 385–386
Bayesian approach , 95–96, 593–594
Baylor College of Medicine , 614–615
B cell lymphomas , 334–335
BeadArray technology , 63–64
Beads, Emulsions, Amplifi cation,
and Magnetics (BEAMing)
technology , 206–207
Becker muscular dystrophy (BMD) , 535
Biobanking and Biomolecular Research
Infrastructure (BBMRI) , 633
Biobanks
CARTaGENE project, in Canada , 634
defi nition , 632
EU biobank , 633–634
Lausanne Institutional Biobank , 634
UK Biobank project , 632–633
Biochips
AmpliChip CYP450 , 49–50
applications of , 45–46
Arrayit ® H25K , 49
defi nition , 44
Gene Profi ling Array , 48
microfl uidics
advantages of , 56
applications of , 56
FISH-on-chip technology , 56–57
LabCD , 58
LabChip , 57
lab-on-a-chip devices , 57Index