No vasopressor or combination of agents show decrease in mortality.
Achieving supraclinical indices of organ and tissue perfusion show no advantage
Ref: Tissue hypoxia how to detect, how to correct, how to prevent. Consensus Conference, AJRCCM 1996.
IV. Tissue Oxygenation
(^) Oxygen delivery at the tissues and cellular level remains difficult to measure.
At the cellular level, there are factors that we know favors the release of oxygen
from hemoglobin molecules. These factors shift the O 2 dissociation curve to the
right and include: ↑ HR, ↓pH, ↑2, 3 DPG, ↑CO 2 , and hypoxia.
(^)