ECMO-/ECLS

2. NSAIDS [13]^

 Clinical indications: potent analgesic and anti-inflammatory.

Treatment of mild to moderate pain.

 Clinical effects: Pain relief by blocking peripheral and central

prostaglandin production by inhibiting cyclooxygenase (COX)

type 1, 2, and 3.

 Advantages: low rate of adverse reactions; no respiratory

depression; no sedative effect; long duration of action; no

tolerance

 Dosing: 5-10mg/kg q6 hours

 Onset: 30 minutes

 Precautions:

o GI bleeding

o hepatotoxicity

o interferes with platelet function

o hematuria

IV. Common Sedatives (See Table 2)