ECMO-/ECLS

and dyskinetic movements of face, tongue, and limbs, depression

of consciousness.

 Precautions in neonates: midazolam and fentanyl given by rapid

infusion can cause severe, life threatening hypotension and

cardiorespiratory arrest in neonates

2. Lorazepam [2,13]^
    Insoluble
    Clinical effects: Prolonged effects on mental status and
   respiratory drive.
    Dosing: 0.05-0.1mg/kg
    Elimination: Half life 10-20 hours
    Precautions: Contains polyethylene glycol 400 in propylene
   glycol, which causes elevated osmolar gap, metabolic
   acidosis, and is nephrotoxic in high doses.
    Avoid use in infants under 6 months of age.
   o Infusions can lead to significant metabolic acidosis and
   acute renal failure in infants