Clinical Stages
Stage 1: A demarcation line separates avascular retina anteriorly from vascular retina
posteriorly.
Stage 2: The demarcation line is now a ridge with height, width and volume. The ridge
extends above the plane of the retina. This regresses spontaneously without sequelae
in 80% of patients.
Stage 3: A ridge is seen with extraretinal fibrovascular proliferation. This is severe
disease with some sequelae to vision expected.
Stage 4-5: Retinal detachment. There is poor prognosis, even with surgery
“Plus disease”: Inflammatory changes. Hazy vitreous. Poor pupillary dilation.
Synechiae. Dilated tortuous vessels. Very guarded prognosis
Follow-Up
Based on retinal maturity & severity of disease.
<= 1week
Stage 1 or 2 ROP: zone 1
Stage 3 ROP: zone 2
1 to 2 weeks
Immature vascularization: zone 1—no ROP
Stage 2 ROP: zone 2
Regressing ROP: zone 1
2 weeks