Stage 1 ROP: zone 2
Regressing ROP: zone 2
2 to 3 weeks
Immature vascularization: zone 2—no ROP
Stag 1 or 2 ROP: zone 3
Regressing ROP: zone 3
Threshold Disease Is
Stage 3 in Zone 1
Stage 3 in 5 continuous clock hours or 8 total clock hours
Stage 3 in Zone 2 with presence of Plus disease
Intervention
Treatment is initiated within 72 hours for:
Zone 1 ROP: any stage with plus disease
Zone 1 ROP: stage 3, no plus disease
Zone 2 ROP: stage 2 or 3 with plus disease
Ablative therapy is considered if threshold disease exists (cryotherapy, laser
photocoagulation
Anti-VEGF injection with Avastin (Genetech/Roche, South San Francisco, CA)
Most often occurs at 38 wks post-conceptional age