hydrogels. F.M.Y. performed and analyzed gel photopatterning
experiments. P.L. designed and analyzed experiments related
to the mechanism of intestinal patterning and provided feedback
on the manuscript. K.S.A. designed the materials and concepts
for photo-controlled symmetry breaking, including design of
experiments and data analysis. All authors read and provided
feedback on the manuscript.Competing interests:Ecole
Polytechnique Fédérale de Lausanne (with M.P.L., N.G., M.N.,
and N.B.) has filed patent applications pertaining to organoid
culture methods described in the paper.Data and materials
availability:All data are available in the main text or the
supplementary materials.SUPPLEMENTARY MATERIALS
science.org/doi/10.1126/science.aaw9021
Materials and Methods
Figs. S1 to S12References ( 48 Ð 51 )
Movies S1 to S8
MDAR Reproducibility Checklist4 February 2019; resubmitted 23 November 2020
Accepted 11 November 2021
10.1126/science.aaw9021Gjorevskiet al.,Science 375 , eaaw9021 (2022) 7 January 2022 9of9
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