Science - USA (2022-01-14)

SCIENCEscience.org 14 JANUARY 2022¥VOL 375 ISSUE 6577 189

A B

CD

F

E

G

H

Wuhan Hu-1

B.1.1.7B.1.351

P. 1

B.1.617.2Wuhan Hu

-^1
B.1.1.7B.1.351

P.^1

B.1.6

17.2

100

1,000

10,000

100,000

1,000,000

Neutralization (IC50)

p < 0.0001

Wuhan Hu-1

B.1.1.7B.1.351

P.^1

B.1.617.2

Wu

han Hu-1B.1

.1.7

B.1.351

P.^1

B.1.617.2

p < 0.0001

p = 0.0001

p = 0.0002

p = 0.0004

Wuhan Hu-1

B.1.

1.7

B.1.351

P.^1

B.1.617.

2

Wuhan Hu-1

B.1.1.7B.1.351

P.1

B.1.61

7.2

p < 0.0001

p < 0.0001

p = 0.0025

Infection wave

VVVaccination

Wuhan Hu- (^1) B.1.1. 7 Wuhan Hu- (^1) B.1. 1. 7 Wuhan Hu- (^1) B.1. 1. 7

• 
  
  
  
  • 
    
    
    
    • 
      
      
      
      • ++ ++
      
      
      
      
    
    
    
    
  
  
  
  

n = (^24) n = 8 n =^24 n = 9 n = 24 n = 34
p < 0.0001
p < 0.0001
p = 0.3125
p = 0.2031
p < 0.0001 p = 0.3880
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
1
10
100
1,000
10,000
100,000
1,000,000
RBD antibody titer
p = 0.0040 p = 0.0188
p < 0.0001
0/11 7/7 8/8 9/10 9/9 9/9241/24170/70 36/36
Infection wave
Vaccination - + ++
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
1
10
100
1,000
SFC per 10
6 PBMC
11/2519/244/6 13/23 22/247/8 20/2224/2426/27
p = 0.0002 p = 0.0006 p = 0.0021
Infection wave
Vaccination - + ++
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
1
10
100
1,000
SFC per 10
6 PBMC
Wuhan Hu-1
pool
B.1.1.7
pool
p = 0.0007
p = 0.0023
14/2315/235/8 8/2318/236/8
Infection wave
UninfectedWuhan Hu-1
B.1.1.7
UninfectedWuhan Hu-1
B.1.1.7
1
10
100
1,000
SFC per 10
6 PBMC
Wuhan Hu-1
pool
B.1.1.7
pool
p = 0.0412
p = 0.0068
p = 0.0543
p = 0.0057
9/2221/2513/2715/2221/24 15/27
Infection wave^100
1,000
10,000
100,000
1,000,000
Neutralization (IC50)
Vaccination- + ++ - +++ - +++ - + ++
Wuhan Hu-1 B.1.1.7 B.1.351 P. 1
p < 0.0001
p = 0.0022
p = 0.0002
p = 0.2680
p < 0.0001 p < 0.0001
p = 0.0131 p = 0.0089
p = 0.5625
p < 0.0001
p < 0.0001
p < 0.0001
p < 0.0001
p = 0.4182

• 
  
  
  
  • ++
    B.1.617.2
  
  
  
  

n = 8

n = 9

n = 34

(^100) 1,00010,0^00
10 0,000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
Wuhan Hu-1
p < 0.0001
r = 0.535
(^00100)
1,000 10,00
0
100,000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.1.7
p < 0.0001
r = 0.683
(^0100) 1,000
10,^000100 ,^00
0
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.351
p < 0.0001
r = 0.577
(^0100)
1,000 10 ,0^0010 0,00
0
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
P. 1
p < 0.0001
r = 0.645
(^1001) ,000 1 0,00^0
100,000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.617.2
p = 0.0137
r = 0.287
(^100) 1, (^00010) , 000
100
,^000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
Wuhan Hu-1
p < 0.0001
r =626
(^1001) , (^000) 10,0^00
100 ,0
00
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.1.7
p = 0.9378
r = 0.011
(^100) 1,00^0 10,00^0
1 00,0
00
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.351
p < 0.0001
r = 0.729
(^100) 1,000 10,000
1 00,000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
P. 1
p < 0.0001
r = 0.752
(^100) 1, (^00010) ,00^0
100 ,
000
100
1,000
10,000
100,000
1,000,000
Roche S1 RBD titer
Neutralization (IC50)
B.1.617.2
p = 0.3698
r = 0.128
RESEARCH | RESEARCH ARTICLES