Science - USA (2022-01-14)

SCIENCEscience.org 14 JANUARY 2022¥VOL 375 ISSUE 6577 191

AB

D

E

C

G

H

I

0 10 20 30

1

10

100

1,000

10,000

100,000

Number of weeks after 2nd dose

RBD antibody titer

n = 270

p < 0.0001

r = -0.545

54

71-72

0.1

1

10

100

% Wuhan Hu-1 S1 specific IgG+ ASC

n = 11

54

71-72

n = 4

Infection wave fected Wuhan Hu- 1

Weeks

p = 0.0098

0 10 20 30

1

10

100

1,000

10,000

100,000

Number of weeks after 2nd dose

RBD antibody titer

n = 154

p < 0.0001

r = -0.537

Uninfected

Wuhan Hu-1

B.1.1.7

1

10

100

1,000

SFC per 10

6 PBMC

Infection wave

18/1916/1915/16

p = 0.0304

UninfectedWuhan Hu-1

B.1.1.7

0.1

1

10

100

% S1 with B.1.617.2 VOC mutations specific IgG+ ASC

p = 0.0138

UninfectedWuhan Hu-1

B.1.1.7

0.1

1

10

100

% Wuhan Hu-1 S1 specific IgG+ ASC

Infection wave

n = 13

n = 11

n = 9

Wuhan Hu-1

B.1.617.2

0.1

1

10

100

% S1 specific IgG+ ASC

Wuhan Hu-1

B.1.617.2

Wuhan Hu-1

B.1.617.2

Infection wave Uninfected Wuhan Hu-1 B.1.1. 7

n = 1 3 n = 11 n =^9

Uninfected

Wuhan Hu-1

B.1.1.7

1

10

100

1,000

10,000

100,000

RBD antibody titer

n = 25

n = 17

n = 14

Infection wave

p = 0.0507

0 10 20 30

100

1,000

10,000

100,000

1,000,000

Number of weeks after 2nd dose

Neutralization (IC50)

0 10 20 30

100

1,000

10,000

100,000

1,000,000

Number of weeks after 2nd dose

Neutralization (IC50)

0 10 20 30

100

1,000

10,000

100,000

1,000,000

Number of weeks after 2nd dose

Neutralization (IC50)

0 10 20 30

100

1,000

10,000

100,000

1,000,000

Number of weeks after 2nd dose

Neutralization (IC50)

Wuhan Hu- 1 B.1.1. 7 B.1.35 1 PPP. 1

0 10 20 30

100

1,000

10,000

100,000

1,000,000

Number of weeks after 2nd dose

Neutralization (IC50)

B.1.617. 2

n = 10 3 n = 10 3 n = 103 n = 10 3 n = 10 3

F

100

1,000

10,000

100,000

1,000,000

Neutralization (IC50)

100

1,000

10,000

100,000

1,000,000

Neutralization (IC50)

VVVaccination - + - - -

Wuhan Hu- (^1) B.1.1. (^7) B.1.35 1 PPP. 1
++ + ++ + ++ + ++
B.1. 6 17.2

• ++
  n = 19 19 19 19 19 19 19 19 19 19 19 16 1919 16
  n = 0 20 0 0 0 0 20 0 20
  16 16 16 19 19
  0 20
  ++
  0 20 20


• 
  

  0 20 20
  ++
  20
  ++
  0 20
  ++
  Weekkks
  16-1
  (^842)
  54-5
  7
  71-7
  2
  1 6-1
  (^842)
  54-5
  7
  71-7
  2
  16-1
  (^842)
  54-5
  7
  7 1-7
  2
  16-1
  (^842)
  54-5
  7
  71-7
  2
  16-1
  (^842)
  54-
  57
  7 1-7
  2
  100
  1,000
  10,000
  100,000
  1,000,000
  Neutralization (IC50)
  n = 23 23 2316 23 23 2316 23 232316 23 23 2316 23 23 23 16
  16-fold 1 23-foldd 2 6-foldd 3 -foldd 589 -foldd 18 -foldd 4445 -foldd 29 -fold 1765-fold 262 -foldd 393 -foldd 233 -fold
  27-foldd 6 -fold 5 -foldd 5 2-foldd 2 3-foldd7-foldd 65-fold 33 -foldd 44 -foldd 6 3-foldd 0 .8-foldd 11 0-foldd 21-foldd3-fold
  6 -fold 13 -fold 7 -fold^4 1-fold
  p < 0.0001
  p < 0.0001
  p < 0.0001 p = 0.0122 p < 0.0001
  p < 0.0001
  p = 0.0039 p < 0.0001
  p < 0.0001
  p = 0.500 p < 0.0001
  p < 0.0001
  p = 0.0059 p < 0.0001
  p < 0.0001
  dd
  p < 0.0001 p = 0.0003
  p< 0.0001
  p < 0.0001 p < 0.0001
  p < 0.0001
  p < 0.0001 p = 0.0042
  p = 0.0005
  p < 0.0001 p = 0.0003
  p = 0.5803
  p < 0.0001 p = 0.0250
  p = 0.0002
  p = 0.0002 p < 0.0001 p = 0.4304 p < 0.0001 p < 0.0001
  6-fold
  RESEARCH | RESEARCH ARTICLES